사람 신경항원에 대한 단세포군 항체의 생산 및 특성 분석

박주영; 신전수; 이경호; 고춘명

doi:Peripheral nerve damage is commonly observed in leprosy patients, but the pathogenic processes of nerve damage are still not well understood. In the present study, we produced monoclonal antibodies to protein components from human central nerve system (CNS) in an attempt to investigate the immunological mechanisms of nerve damage and to detect nerve antigen from sera in leprosy patients. Seven monoclonal antibodies (six were IgG1 and one was IgG2a in iso type) were produced; five antibodies were reactive with 38 kDa AND 43 kDa molecules from human CNS; other two antibodies were cross-reactive with human myelin basic protein and human muscle protein in ELISA. No antibody was reactive with rabbit peripheral nerve system protein. Although further 
evaluations of these antibodies are required to know the specific binding site of CNS protein and the reactivity to other tissue protein, this study suggests that the monoclonal antibodies may be useful in studying the immunological mechanisms of nerve damage in leprosy.

YUHSpace

BROWSE

8 300

Cited 0 times in

사람 신경항원에 대한 단세포군 항체의 생산 및 특성 분석

DC Field	Value	Language
dc.contributor.author	신전수	-
dc.date.accessioned	2021-09-28T07:42:53Z	-
dc.date.available	2021-09-28T07:42:53Z	-
dc.date.issued	1996-03	-
dc.identifier.issn	0253-3162	-
dc.identifier.uri	https://ir.ymlib.yonsei.ac.kr/handle/22282913/183123	-
dc.description.statementOfResponsibility	restriction	-
dc.language	Korean	-
dc.publisher	Korean Society for Microbiology	-
dc.relation.isPartOf	Journal of the Korean Society for Microbiology(대한미생물학회지)	-
dc.rights	CC BY-NC-ND 2.0 KR	-
dc.title	사람 신경항원에 대한 단세포군 항체의 생산 및 특성 분석	-
dc.title.alternative	Production and Characterization of Monoclonal Antibodies to Human Nerve Specific Antigen	-
dc.type	Article	-
dc.contributor.college	College of Medicine (의과대학)	-
dc.contributor.department	Dept. of Microbiology (미생물학교실)	-
dc.contributor.googleauthor	박주영	-
dc.contributor.googleauthor	신전수	-
dc.contributor.googleauthor	이경호	-
dc.contributor.googleauthor	고춘명	-
dc.identifier.doi	Peripheral nerve damage is commonly observed in leprosy patients, but the pathogenic processes of nerve damage are still not well understood. In the present study, we produced monoclonal antibodies to protein components from human central nerve system (CNS) in an attempt to investigate the immunological mechanisms of nerve damage and to detect nerve antigen from sera in leprosy patients. Seven monoclonal antibodies (six were IgG1 and one was IgG2a in iso type) were produced; five antibodies were reactive with 38 kDa AND 43 kDa molecules from human CNS; other two antibodies were cross-reactive with human myelin basic protein and human muscle protein in ELISA. No antibody was reactive with rabbit peripheral nerve system protein. Although further evaluations of these antibodies are required to know the specific binding site of CNS protein and the reactivity to other tissue protein, this study suggests that the monoclonal antibodies may be useful in studying the immunological mechanisms of nerve damage in leprosy.	-
dc.contributor.localId	A02144	-
dc.relation.journalcode	J03751	-
dc.identifier.url	https://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE01486739	-
dc.contributor.alternativeName	Shin, Jeon Soo	-
dc.contributor.affiliatedAuthor	신전수	-
dc.citation.volume	31	-
dc.citation.number	1	-
dc.citation.startPage	69	-
dc.citation.endPage	74	-
dc.identifier.bibliographicCitation	Journal of the Korean Society for Microbiology (대한미생물학회지), Vol.31(1) : 69-74, 1996-03	-

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

Show simple item record Find it @ YMLIB

License

YUHSpace: 사람 신경항원에 대한 단세포군 항체의 생산 및 특성 분석

YUHSpace

BROWSE

Browse

Links