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Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy

Authors
 Jiwon Seo  ;  Yoo Jin Hong  ;  Young Jin Kim  ;  Purevjargal Lkhagvasuren  ;  Iksung Cho  ;  Chi Young Shim  ;  Jong-Won Ha  ;  Geu-Ru Hong 
Citation
 SCIENTIFIC REPORTS, Vol.10(1) : 21908, 2020-12 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2020-12
MeSH
Adult ; Aged ; Cardiomyopathy, Hypertrophic / diagnostic imaging* ; Cardiomyopathy, Hypertrophic / mortality ; Cardiomyopathy, Hypertrophic / physiopathology* ; Cardiomyopathy, Hypertrophic / surgery ; Echocardiography* ; Female ; Heart Ventricles / diagnostic imaging* ; Heart Ventricles / physiopathology* ; Humans ; Magnetic Resonance Imaging* ; Male ; Middle Aged ; Models, Cardiovascular* ; Prevalence ; Ventricular Dysfunction, Right / diagnostic imaging* ; Ventricular Dysfunction, Right / mortality ; Ventricular Dysfunction, Right / physiopathology* ; Ventricular Dysfunction, Right / surgery
Abstract
We sought to investigate the prevalence, functional characteristics, and clinical significance of right ventricular (RV) involvement in patients with hypertrophic cardiomyopathy (HCM). A total of 256 patients with HCM who underwent both cardiac magnetic resonance (CMR) imaging and transthoracic echocardiography within 6 months of each other were retrospectively analysed. RV involvement was defined as an increased RV wall thickness ≥ 7 mm on CMR in the segments of the RV free wall. Primary outcomes were defined as the composite of all-cause death, heart transplantation, and unplanned cardiovascular admission. Thirty-seven (14.4%) patients showed RV involvement. Patients with RV involvement showed a significantly higher left ventricular (LV) maximal wall thickness and left atrial volume index. Multivariate Cox model revealed that RV involvement was independently associated with primary outcomes (HR: 2.30, p = 0.024). In a subgroup analysis of patients with speckle tracking echocardiography (n = 190), those with RV involvement had significantly more impaired RV strain, which was independently associated with primary outcomes. RV involvement in patients with HCM correlated with more advanced LV structure and biventricular dysfunction, suggesting an indicator of severe HCM. RV involvement and impaired RV strain have a prognostic value related to clinical adverse events in patients with HCM.
Files in This Item:
T202006325.pdf Download
DOI
10.1038/s41598-020-78945-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Seo, Jiwon(서지원) ORCID logo https://orcid.org/0000-0002-7641-3739
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Cho, Ik Sung(조익성)
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
Hong, Geu Ru(홍그루) ORCID logo https://orcid.org/0000-0003-4981-3304
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182606
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