12 19

Cited 0 times in

A radiomics-based model for predicting prognosis of locally advanced gastric cancer in the preoperative setting

 Jaeseung Shin  ;  Joon Seok Lim  ;  Yong-Min Huh  ;  Jie-Hyun Kim  ;  Woo Jin Hyung  ;  Jae-Joon Chung  ;  Kyunghwa Han  ;  Sungwon Kim 
 SCIENTIFIC REPORTS, Vol.11(1) : 1879, 2021-01 
Journal Title
Issue Date
This study aims to evaluate the performance of a radiomic signature-based model for predicting recurrence-free survival (RFS) of locally advanced gastric cancer (LAGC) using preoperative contrast-enhanced CT. This retrospective study included a training cohort (349 patients) and an external validation cohort (61 patients) who underwent curative resection for LAGC in 2010 without neoadjuvant therapies. Available preoperative clinical factors, including conventional CT staging and endoscopic data, and 438 radiomic features from the preoperative CT were obtained. To predict RFS, a radiomic model was developed using penalized Cox regression with the least absolute shrinkage and selection operator with ten-fold cross-validation. Internal and external validations were performed using a bootstrapping method. With the final 410 patients (58.2 ± 13.0 years-old; 268 female), the radiomic model consisted of seven selected features. In both of the internal and the external validation, the integrated area under the receiver operating characteristic curve values of both the radiomic model (0.714, P < 0.001 [internal validation]; 0.652, P = 0.010 [external validation]) and the merged model (0.719, P < 0.001; 0.651, P = 0.014) were significantly higher than those of the clinical model (0.616; 0.594). The radiomics-based model on preoperative CT images may improve RFS prediction and high-risk stratification in the preoperative setting of LAGC.
Files in This Item:
T202101004.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sungwon(김성원) ORCID logo https://orcid.org/0000-0001-5455-6926
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Shin, Jaeseung(신재승) ORCID logo https://orcid.org/0000-0002-6755-4732
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.