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Omega-3 fatty acids supplementation on major cardiovascular outcomes: an umbrella review of meta-analyses of observational studies and randomized controlled trials

Authors
 H Choi  ;  J Y Kim  ;  K H Lee  ;  J S Kim  ;  J Y Lee  ;  E K Choi  ;  H J Seong  ;  G Kim  ;  H Park  ;  E Jung  ;  S H Hong  ;  A Kronbichler  ;  M Eisenhut  ;  A Koyanagi  ;  L Jacob  ;  D K Yon  ;  S W Lee  ;  M S Kim  ;  K Kostev  ;  J I Shin  ;  J W Yang  ;  L Smith 
Citation
 EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, Vol.25(4) : 2079-2092, 2021-02 
Journal Title
 EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 
ISSN
 1128-3602 
Issue Date
2021-02
Abstract
Objective: Omega-3 fatty acids are commonly used as a lipid-lowering agent or dietary supplement for the purpose of prevention of cardiovascular diseases. However, even large-scale clinical trials have not shown significant results demonstrating clear clinical benefits in cardiovascular diseases. Thus, this umbrella review aims to summarize and evaluate the evidence of clinical effects of omega-3 fatty acids supplementation on cardiovascular outcomes through comprehensive analyses of previous randomized controlled trials (RCTs) or observational cohort studies. Materials and methods: We conducted relevant publication search in PubMed, Embase, and Cochrane Database of Systematic Reviews. We retrieved and analyzed 3,298 articles published until August 28th, 2019. Results: We identified 29 relevant articles and analyzed 83 meta-analyses of RCTs or cohort studies therefrom. As a result, we identified 12 cardiovascular outcomes that are related to omega-3 fatty acids supplementation. Among them, total mortality from major cardiovascular causes (RR 0.92, 95% CI 0.86 to 0.98) had significant inverse associations, and moreover, statistical significances were maintained even in subgroup analysis of large-scale RCTs including more than 1,000 patients (RR 0.94, 95% CI 0.88 to 0.99). Conclusions: Our umbrella review study shows that omega-3 fatty acids supplementation have a clinical benefit in reducing mortality from cardiovascular causes. However, many studies still have shown conflicting results, and therefore, further studies will be needed to verify the clinical benefit of omega-3 supplementation.
Files in This Item:
T202100676.pdf Download
DOI
10.26355/eurrev_202102_25113
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
Choi, Eun Kyoung(최은경) ORCID logo https://orcid.org/0000-0003-4622-2437
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182216
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