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Diverse patterns of bone regeneration in rabbit calvarial defects depending on the type of collagen membrane

Authors
 Inpyo Hong  ;  Alharthi Waleed Khalid  ;  Hyung Chul Pae  ;  Young Woo Song  ;  Jae Kook Cha  ;  Jung Seok Lee  ;  Jeong Won Paik  ;  Seong Ho Choi 
Citation
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.50(1) : 40-52, 2021-02 
Journal Title
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE 
ISSN
 2093-2278 
Issue Date
2021-02
Keywords
Bone regeneration ; Collagen ; Ultraviolet rays
Abstract
Purpose: Various crosslinking methods have been introduced to increase the longevity of collagen membranes. The aim of this study was to compare and evaluate the degradation and bone regeneration patterns of 3 collagen membranes. Methods: Four 8-mm-diameter circular bone defects were created in the calvaria of 10 rabbits. In each rabbit, each defect was randomly allocated to 1) the sham control group, 2) the non-crosslinked collagen sponge (NS) group, 3) the chemically crosslinked collagen membrane (CCM) group, or 4) the biphasic calcium phosphate (BCP)-supplemented ultraviolet (UV)-crosslinked collagen membrane (UVM) group. Each defect was covered with the allocated membrane without any graft material. Rabbits were sacrificed at either 2 or 8 weeks post-surgery, and radiographic and histologic analyses were done. Results: New bone formed underneath the membrane in defects in the CCM and UVM groups, with a distinctive new bone formation pattern, while new bone formed from the base of the defect in the NS and control groups. The CCM maintained its shape until 8 weeks, while the UVM and NS were fully degraded at 8 weeks; simultaneously, sustained inflammatory infiltration was found in the margin of the CCM, while it was absent in the UVM. In conclusion, the CCM showed longer longevity than the UVM, but was accompanied by higher levels of inflammation. Conclusions: Both the CCM and UVM showed distinctive patterns of enhancement in new bone formation in the early phase. UV crosslinking can be a biocompatible alternative to chemical crosslinking.
Files in This Item:
T202100593.pdf Download
DOI
10.5051/jpis.2004180209
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Paik, Jeong Won(백정원) ORCID logo https://orcid.org/0000-0002-5554-8503
Song, Young Woo(송영우) ORCID logo https://orcid.org/0000-0003-1835-5646
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182197
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