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Pulmonary Embolism and Deep Vein Thrombosis in COVID-19: A Systematic Review and Meta-Analysis

 Young Joo Suh  ;  Hyunsook Hong  ;  Mickaël Ohana  ;  Florian Bompard  ;  Marie-Pierre Revel  ;  Clarissa Valle  ;  Alban Gervaise  ;  Julien Poissy  ;  Sophie Susen  ;  Guillaume Hékimian  ;  Mathieu Artifoni  ;  Daniel Periard  ;  Damien Contou  ;  Julie Delaloye  ;  Bienvenido Sanchez  ;  Cheng Fang  ;  Giorgio Garzillo  ;  Hasti Robbie  ;  Soon Ho Yoon 
 RADIOLOGY, Vol.298(2) : E70-E80, 2021-02 
Journal Title
Issue Date
COVID-19 / blood ; COVID-19 / complications* ; COVID-19 / diagnosis* ; Computed Tomography Angiography / methods ; Fibrin Fibrinogen Degradation Products / analysis ; Humans ; Pulmonary Embolism / blood ; Pulmonary Embolism / complications* ; Pulmonary Embolism / diagnostic imaging* ; SARS-CoV-2 ; Venous Thrombosis / blood ; Venous Thrombosis / complications* ; Venous Thrombosis / diagnostic imaging*
Background The association of pulmonary embolism (PE) with deep vein thrombosis (DVT) in patients with coronavirus disease 2019 (COVID-19) remains unclear, and the diagnostic accuracy of D-dimer tests for PE is unknown. Purpose To conduct meta-analysis of the study-level incidence of PE and DVT and to evaluate the diagnostic accuracy of D-dimer tests for PE from multicenter individual patient data. Materials and Methods A systematic literature search identified studies evaluating the incidence of PE or DVT in patients with COVID-19 from January 1, 2020, to June 15, 2020. These outcomes were pooled using a random-effects model and were further evaluated using metaregression analysis. The diagnostic accuracy of D-dimer tests for PE was estimated on the basis of individual patient data using the summary receiver operating characteristic curve. Results Twenty-seven studies with 3342 patients with COVID-19 were included in the analysis. The pooled incidence rates of PE and DVT were 16.5% (95% CI: 11.6, 22.9; I2 = 0.93) and 14.8% (95% CI: 8.5, 24.5; I2 = 0.94), respectively. PE was more frequently found in patients who were admitted to the intensive care unit (ICU) (24.7% [95% CI: 18.6, 32.1] vs 10.5% [95% CI: 5.1, 20.2] in those not admitted to the ICU) and in studies with universal screening using CT pulmonary angiography. DVT was present in 42.4% of patients with PE. D-dimer tests had an area under the receiver operating characteristic curve of 0.737 for PE, and D-dimer levels of 500 and 1000 μg/L showed high sensitivity (96% and 91%, respectively) but low specificity (10% and 24%, respectively). Conclusion Pulmonary embolism (PE) and deep vein thrombosis (DVT) occurred in 16.5% and 14.8% of patients with coronavirus disease 2019 (COVID-19), respectively, and more than half of patients with PE lacked DVT. The cutoffs of D-dimer levels used to exclude PE in preexisting guidelines seem applicable to patients with COVID-19. © RSNA, 2020 Supplemental material is available for this article. See also the editorial by Woodard in this issue.
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Yonsei Authors
Suh, Young Joo(서영주) ORCID logo https://orcid.org/0000-0002-2078-5832
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