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Potential role of stress-induced gluconeogenesis in disease aggravation and mortality in pyruvate dehydrogenase deficiency: A case-based hypothesis

Authors
 Jiyoung Oh  ;  Chungmo Koo  ;  Kyung Won Kim  ;  Jin-Sung Lee 
Citation
 MEDICAL HYPOTHESES, Vol.146 : 110432, 2021-01 
Journal Title
 MEDICAL HYPOTHESES 
ISSN
 0306-9877 
Issue Date
2021-01
Keywords
Ketogenic diet ; Pyruvate dehydrogenase deficiency ; Stress-induced hyperglycemia
Abstract
Pyruvate dehydrogenase (PDH) deficiency is an inherited metabolic disorder caused by a defect in any subunit of the pyruvate dehydrogenase complex (PDHC), which has an essential role in glucose metabolism. The causes of disease progression in PDH deficiency are not fully understood yet. Based on repeated observations of a patient with PDH deficiency at our center, we hypothesized that stress-induced gluconeogenesis contributes to rapid exacerbation of the disease. This link has not been established previously.
Full Text
https://www.sciencedirect.com/science/article/pii/S0306987720333235
DOI
10.1016/j.mehy.2020.110432
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Koo, Chung Mo(구청모)
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Oh, Ji Young(오지영) ORCID logo https://orcid.org/0000-0003-3552-8465
Lee, Jin-Sung(이진성) ORCID logo https://orcid.org/0000-0002-1262-8597
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182038
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