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Potential role of stress-induced gluconeogenesis in disease aggravation and mortality in pyruvate dehydrogenase deficiency: A case-based hypothesis
DC Field | Value | Language |
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dc.contributor.author | 구청모 | - |
dc.contributor.author | 김경원 | - |
dc.contributor.author | 오지영 | - |
dc.contributor.author | 이진성 | - |
dc.date.accessioned | 2021-04-29T16:49:27Z | - |
dc.date.available | 2021-04-29T16:49:27Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0306-9877 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182038 | - |
dc.description.abstract | Pyruvate dehydrogenase (PDH) deficiency is an inherited metabolic disorder caused by a defect in any subunit of the pyruvate dehydrogenase complex (PDHC), which has an essential role in glucose metabolism. The causes of disease progression in PDH deficiency are not fully understood yet. Based on repeated observations of a patient with PDH deficiency at our center, we hypothesized that stress-induced gluconeogenesis contributes to rapid exacerbation of the disease. This link has not been established previously. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Eden Press | - |
dc.relation.isPartOf | MEDICAL HYPOTHESES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Potential role of stress-induced gluconeogenesis in disease aggravation and mortality in pyruvate dehydrogenase deficiency: A case-based hypothesis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | ;Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Jiyoung Oh | - |
dc.contributor.googleauthor | Chungmo Koo | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Jin-Sung Lee | - |
dc.identifier.doi | 10.1016/j.mehy.2020.110432 | - |
dc.contributor.localId | A06014 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A02399 | - |
dc.contributor.localId | A03227 | - |
dc.relation.journalcode | J02200 | - |
dc.identifier.eissn | 1532-2777 | - |
dc.identifier.pmid | 33303308 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0306987720333235 | - |
dc.subject.keyword | Ketogenic diet | - |
dc.subject.keyword | Pyruvate dehydrogenase deficiency | - |
dc.subject.keyword | Stress-induced hyperglycemia | - |
dc.contributor.alternativeName | Koo, Chung Mo | - |
dc.contributor.affiliatedAuthor | 구청모 | - |
dc.contributor.affiliatedAuthor | 김경원 | - |
dc.contributor.affiliatedAuthor | 오지영 | - |
dc.contributor.affiliatedAuthor | 이진성 | - |
dc.citation.volume | 146 | - |
dc.citation.startPage | 110432 | - |
dc.identifier.bibliographicCitation | MEDICAL HYPOTHESES, Vol.146 : 110432, 2021-01 | - |
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