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Potential role of stress-induced gluconeogenesis in disease aggravation and mortality in pyruvate dehydrogenase deficiency: A case-based hypothesis

DC Field Value Language
dc.contributor.authorOh, Jiyoung-
dc.contributor.authorKoo, Chungmo-
dc.contributor.authorKim, Kyung Won-
dc.contributor.authorLee, Jin-Sung-
dc.date.accessioned2021-04-29T16:49:27Z-
dc.date.available2021-04-29T16:49:27Z-
dc.date.created2021-02-22-
dc.date.issued2021-01-
dc.identifier.issn0306-9877-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182038-
dc.description.abstractPyruvate dehydrogenase (PDH) deficiency is an inherited metabolic disorder caused by a defect in any subunit of the pyruvate dehydrogenase complex (PDHC), which has an essential role in glucose metabolism. The causes of disease progression in PDH deficiency are not fully understood yet. Based on repeated observations of a patient with PDH deficiency at our center, we hypothesized that stress-induced gluconeogenesis contributes to rapid exacerbation of the disease. This link has not been established previously.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherEden Press-
dc.relation.isPartOfMEDICAL HYPOTHESES-
dc.relation.isPartOfMEDICAL HYPOTHESES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePotential role of stress-induced gluconeogenesis in disease aggravation and mortality in pyruvate dehydrogenase deficiency: A case-based hypothesis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.department;Dept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorOh, Jiyoung-
dc.contributor.googleauthorKoo, Chungmo-
dc.contributor.googleauthorKim, Kyung Won-
dc.contributor.googleauthorLee, Jin-Sung-
dc.identifier.doi10.1016/j.mehy.2020.110432-
dc.relation.journalcodeJ02200-
dc.identifier.eissn1532-2777-
dc.subject.keywordPyruvate dehydrogenase deficiency-
dc.subject.keywordStress-induced hyperglycemia-
dc.subject.keywordKetogenic diet-
dc.contributor.alternativeNameKoo, Chung Mo-
dc.contributor.affiliatedAuthorOh, Jiyoung-
dc.contributor.affiliatedAuthorKoo, Chungmo-
dc.contributor.affiliatedAuthorKim, Kyung Won-
dc.contributor.affiliatedAuthorLee, Jin-Sung-
dc.identifier.scopusid2-s2.0-85099514086-
dc.identifier.wosid000614812300026-
dc.citation.volume146-
dc.citation.startPage1-
dc.citation.endPage6-
dc.identifier.bibliographicCitationMEDICAL HYPOTHESES, Vol.146 : 1-6, 2021-01-
dc.identifier.rimsid67756-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.journalClass1-
dc.subject.keywordAuthorPyruvate dehydrogenase deficiency-
dc.subject.keywordAuthorStress-induced hyperglycemia-
dc.subject.keywordAuthorKetogenic diet-
dc.subject.keywordPlusCOMPLEX DEFICIENCY-
dc.subject.keywordPlusKETOGENIC DIET-
dc.subject.keywordPlusPDHA1 GENE-
dc.subject.keywordPlusMUTATION-
dc.subject.keywordPlusDICHLOROACETATE-
dc.subject.keywordPlusSPECTRUM-
dc.subject.keywordPlusDEFECTS-
dc.subject.keywordPlusPATIENT-
dc.type.docType원저 (Original Article)-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.identifier.articleno110432-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
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