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Intracranial Aneurysms Are Associated With Marfan Syndrome Single Cohort Retrospective Study in 118 Patients Using Brain Imaging

 Kim, Jae Ho  ;  Kim, Jin Woo  ;  Song, Suk-Won  ;  Ahn, Sung Jun  ;  Park, Mina  ;  Park, Sang Kyu  ;  Suh, Sang Hyun 
 STROKE, Vol.52(1) : 331-334, 2021-01 
Journal Title
Issue Date
aortic diseases ; cohort study ; intracranial aneurysm ; Marfan syndrome ; prevalence
Background and Purpose: The association between intracranial aneurysms (IAs) and Marfan syndrome (MFS) is controversial. We aimed to evaluate the prevalence and characteristics of IAs in patients with MFS using brain imaging and compare it with the general population. Methods: Between 2007 and 2020, 118 patients with confirmed MFS who underwent brain imaging were enrolled and classified into 2 groups; IA group versus non-IA. Demographic data were acquired from their medical records, including age, sex, comorbidities, and aortic diseases. Two readers reviewed all brain images independently regarding the presence, morphology, size, and location of IAs. All data were compared between both groups, and IA characteristics in MFS were analyzed using a database of controls with IAs. Results: The prevalence of IAs was 11.9% in patients with MFS. IA group were significantly older in age (44.6 +/- 12.1 years in IA versus 36.8 +/- 14.0 years in non-IA, P=0.039) and had female predominance (71.4% in IA versus 43.3% in non-IA, P=0.047). All IAs were unruptured, and there was no subarachnoid hemorrhage during the follow-up period (mean; 53.5 +/- 43.3 months). The mean diameter of IAs was significantly larger (4.23 +/- 1.80 mm in MFS versus 3.04 +/- 1.57 mm in control, P=0.004). IAs with MFS were frequently located in the vertebrobasilar artery (33.3% in MFS versus 2.1% in control, P=0.002) and more common in fusiform morphology (13.3% in MFS versus 1.1% in control, P=0.048). Conclusions: This large-cohort study demonstrated a high prevalence and differential features of IAs in MFS, which may support the association between IAs and MFS.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Woo(김진우) ORCID logo https://orcid.org/0000-0003-3155-0569
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
Suh, Sang Hyun(서상현) ORCID logo https://orcid.org/0000-0002-7098-4901
Song, Suk Won(송석원) ORCID logo https://orcid.org/0000-0002-9850-9707
Ahn, Sung Jun(안성준) ORCID logo https://orcid.org/0000-0003-0075-2432
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