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Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea

Authors
 B Yoo  ;  S H Lee  ;  S Y Kim  ;  A Y Leem  ;  K S Chung  ;  E Y Kim  ;  J Y Jung  ;  Y A Kang  ;  M S Park  ;  J Chang  ;  Y S Kim  ;  Y Park 
Citation
 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol.23(11) : 1228-1234, 2019-11 
Journal Title
 INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 
ISSN
 1027-3719 
Issue Date
2019-11
MeSH
Airway Obstruction / blood ; Airway Obstruction / epidemiology* ; Airway Obstruction / physiopathology ; Biomarkers / blood ; C-Reactive Protein / analysis* ; Female ; Forced Expiratory Volume ; Humans ; Linear Models ; Lung / physiopathology* ; Male ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive / blood ; Pulmonary Disease, Chronic Obstructive / epidemiology* ; Pulmonary Disease, Chronic Obstructive / physiopathology ; Republic of Korea / epidemiology ; Severity of Illness Index ; Spirometry ; Vital Capacity
Abstract
OBJECTIVE: To examine the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and lung function in a community-based cohort of South Korea.DESIGN: The Ansung-Ansan cohort database (an ongoing prospective study of a community-based population) was used in the analysis. We defined airway obstruction as the ratio between forced expiratory volume in 1 sec:forced vital capacity ratio (FEV1:FVC) of <95% of the predicted value for a healthy person. We also used the serum level of hs-CRP as a marker of inflammation. Multivariate analysis was performed with adjustment for the clinical characteristics of the participants.RESULTS: A total of 5528 individuals were eligible for the study. The average age was 55.1 years, and 47.8% were males. The prevalence of airway obstruction was 9.0%, and the mean hs-CRP level was 1.51 mg/dl. Serum hs-CRP levels increased with the severity of airway obstruction, and the latter worsened with an increase in the hs-CRP level. In multivariate analysis, as the hs-CRP level increased, FEV1 and FVC decreased. A higher FEV1:FVC ratio was associated with lower hs-CRP levels in males.CONCLUSION: Higher hs-CRP levels were associated with decreased FEV1 and FVC in a general population of Korea. The FEV1:FVC ratio decreased with an increase in the hs-CRP level in males.
Full Text
https://www.ingentaconnect.com/content/iuatld/ijtld/2019/00000023/00000011/art00016;jsessionid=1q765eh3l7q6a.x-ic-live-03
DOI
10.5588/ijtld.18.0848
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Youngmok(박영목) ORCID logo https://orcid.org/0000-0002-5669-1491
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181602
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