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Relationship between airway obstruction and C-reactive protein levels in a community-based population of Korea

DC FieldValueLanguage
dc.contributor.author박영목-
dc.date.accessioned2021-02-03T05:56:19Z-
dc.date.available2021-02-03T05:56:19Z-
dc.date.issued2019-11-
dc.identifier.issn1027-3719-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181602-
dc.description.abstractOBJECTIVE: To examine the relationship between high-sensitivity C-reactive protein (hs-CRP) levels and lung function in a community-based cohort of South Korea.DESIGN: The Ansung-Ansan cohort database (an ongoing prospective study of a community-based population) was used in the analysis. We defined airway obstruction as the ratio between forced expiratory volume in 1 sec:forced vital capacity ratio (FEV1:FVC) of <95% of the predicted value for a healthy person. We also used the serum level of hs-CRP as a marker of inflammation. Multivariate analysis was performed with adjustment for the clinical characteristics of the participants.RESULTS: A total of 5528 individuals were eligible for the study. The average age was 55.1 years, and 47.8% were males. The prevalence of airway obstruction was 9.0%, and the mean hs-CRP level was 1.51 mg/dl. Serum hs-CRP levels increased with the severity of airway obstruction, and the latter worsened with an increase in the hs-CRP level. In multivariate analysis, as the hs-CRP level increased, FEV1 and FVC decreased. A higher FEV1:FVC ratio was associated with lower hs-CRP levels in males.CONCLUSION: Higher hs-CRP levels were associated with decreased FEV1 and FVC in a general population of Korea. The FEV1:FVC ratio decreased with an increase in the hs-CRP level in males.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherThe Union-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAirway Obstruction / blood-
dc.subject.MESHAirway Obstruction / epidemiology*-
dc.subject.MESHAirway Obstruction / physiopathology-
dc.subject.MESHBiomarkers / blood-
dc.subject.MESHC-Reactive Protein / analysis*-
dc.subject.MESHFemale-
dc.subject.MESHForced Expiratory Volume-
dc.subject.MESHHumans-
dc.subject.MESHLinear Models-
dc.subject.MESHLung / physiopathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProspective Studies-
dc.subject.MESHPulmonary Disease, Chronic Obstructive / blood-
dc.subject.MESHPulmonary Disease, Chronic Obstructive / epidemiology*-
dc.subject.MESHPulmonary Disease, Chronic Obstructive / physiopathology-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSpirometry-
dc.subject.MESHVital Capacity-
dc.titleRelationship between airway obstruction and C-reactive protein levels in a community-based population of Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorB Yoo-
dc.contributor.googleauthorS H Lee-
dc.contributor.googleauthorS Y Kim-
dc.contributor.googleauthorA Y Leem-
dc.contributor.googleauthorK S Chung-
dc.contributor.googleauthorE Y Kim-
dc.contributor.googleauthorJ Y Jung-
dc.contributor.googleauthorY A Kang-
dc.contributor.googleauthorM S Park-
dc.contributor.googleauthorJ Chang-
dc.contributor.googleauthorY S Kim-
dc.contributor.googleauthorY Park-
dc.identifier.doi10.5588/ijtld.18.0848-
dc.contributor.localIdA05828-
dc.relation.journalcodeJ01167-
dc.identifier.eissn1815-7920-
dc.identifier.pmid31718761-
dc.identifier.urlhttps://www.ingentaconnect.com/content/iuatld/ijtld/2019/00000023/00000011/art00016;jsessionid=1q765eh3l7q6a.x-ic-live-03-
dc.contributor.alternativeNamePark, Youngmok-
dc.contributor.affiliatedAuthor박영목-
dc.citation.volume23-
dc.citation.number11-
dc.citation.startPage1228-
dc.citation.endPage1234-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol.23(11) : 1228-1234, 2019-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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