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3D microcalcification detection using a color Doppler twinkling artifact with optimized transmit conditions: Preliminary results

 Jinbum Kang 1  ;  Kanghee Han 1  ;  Kang-Sik Kim 2  ;  Won Seuk Jang 3  ;  Min Jung Kim 4  ;  Yangmo Yoo 1 5 
 MEDICAL PHYSICS, Vol.47(12) : 6171-6178, 2020-12 
Journal Title
Issue Date
3D volume reconstruction ; color Doppler twinkling artifact ; human breast surgical specimen ; mammography ; microcalcification
Purpose: Mammography is the only method that has been proven to detect breast microcalcifications (MCs), but the sensitivity of mammography varies according to breast density. This paper proposes an ultrasound (US) color Doppler twinkling artifact (CDTA) method with optimized transmit conditions to identify breast MCs without ionizing radiation.

Methods: The transmit conditions for US color Doppler imaging (CDI) were optimized to enhance the sensitivity of the twinkling artifact (TA) that arises from random scattering on rough surfaces of breast MCs. To validate the proposed breast MC detection method, a chicken breast phantom with MC particles (groups of particles <400 μm
and <240 μm
) was fabricated and scanned by a digital mammography system and an US research platform by an L11-5v linear array probe with a three-dimensional (3D) motion tracking system.

Results: From the phantom experiment, the proposed 3D CDTA imaging method with optimized transmit conditions (i.e., a center frequency of 5.0 MHz, an f-number of 1.3, and a peak negative pressure of 1.83 MPa) successfully detected all 16 MC particles, comparable to detection with mammography. For a human breast surgical specimen in the ex vivo study, all 10 MC clusters, marked by a radiologist on the mammogram, were identified with the proposed 3D CDTA imaging method.

Conclusions: In the phantom and ex vivo breast specimen studies, the proposed 3D CDTA imaging method successfully detected MCs, and the spatial localization was highly correlated with the mammogram results. These results indicate that the proposed 3D CDTA imaging method has great potential for the detection of MCs without ionizing radiation.
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1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0002-4925-3549
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