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나노기둥구조 크기가 섬유아세포의 증식 및 alpha-smooth muscle actin (α-SMA)의 발현에 미치는 영향

Other Titles
 The influence of nanopillar structure size to fibroblast’s proliferation and alpha-smooth muscle actin (α-SMA) expression 
 강은혜  ;  이상수  ;  윤영식  ;  이원재  ;  여종석  ;  노태석  ;  윤인식 
 Journal of Korean Skull Base Society, Vol.15(2) : 98-104, 2020-10 
Journal Title
 Journal of Korean Skull Base Society 
Issue Date
Nanopillar ; Fibroblast ; Cell attachment ; Cell proliferation
Backgound : With advances in medicine and materials engineering, biomaterials, such as silicone and titanium are used in many tissue regeneration cases. Many studies are being conducted to confirm the reactivity of cells to various biomaterials. Among these studies, fibroblast proliferation and differentiation are known as important factors related to capsulation. In this study, we attempted to determine how various sized polyurethane acrylate (PUA) nanopillar structures act on fibroblast proliferation and differentiation. Methods : The scaffolds were prepared in four groups: flat and nanopillar (350 nm, 500 nm, 1,000 nm). Flat group was used as a control. To evaluate the effect of scaffolds of nanopillar structures on fibroblasts, quantitatively analyzed for the degree of adhesion, proliferation and alpha-smooth muscle actin (α-SMA) expression of cells. Results : As a result of the MTT assay, the proliferation was lower than that of the flat group in the nanopillar group. As a result of staining, the intensity of F-actin was significantly different from that of the flat group. And the intensity of α-SMA was different from that of the flat group but not significantly. Conclusions : The nanopillar structure of PUA material seems to play a role in inhibiting the proliferation and differentiation of fibroblasts regardless of the size of the structure. This suggests that the use of PUA nanopillar implants may be effective in suppressing fibrosis due to fibroblast proliferation and differentiation.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Tai Suk(노태석) ORCID logo https://orcid.org/0000-0001-8681-159X
Yun, In Sik(윤인식) ORCID logo https://orcid.org/0000-0003-1103-7047
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
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