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Antifibrotic effects of sulforaphane treatment on gingival elasticity reduces orthodontic relapse after rotational tooth movement in beagle dogs

Authors
 Kyong-Nim Kim  ;  Jue-Young Kim  ;  Jung-Yul Cha  ;  Sung-Hwan Choi  ;  Jin Kim  ;  Sung-Won Cho  ;  Chung-Ju Hwang 
Citation
 KOREAN JOURNAL OF ORTHODONTICS, Vol.50(6) : 391-400, 2020-11 
Journal Title
 KOREAN JOURNAL OF ORTHODONTICS 
ISSN
 2234-7518 
Issue Date
2020-11
Keywords
Gingival elasticity ; Relapse ; Rotation ; Sulforaphane
Abstract
Objective: Increased gingival elasticity has been implicated as the cause of relapse following orthodontic rotational tooth movement and approaches to reduce relapse are limited. This study aimed to investigate the effects of sulforaphane (SFN), an inhibitor of osteoclastogenesis, on gene expression in gingival fibroblasts and relapse after rotational tooth movement in beagle dogs. Methods: The lower lateral incisors of five beagle dogs were rotated. SFN or dimethylsulfoxide (DMSO) were injected into the supra-alveolar gingiva of the experimental and control group, respectively, and the effect of SFN on relapse tendency was evaluated. Changes in mRNA expression of extracellular matrix components associated with gingival elasticity in beagles were investigated by real-time polymerase chain reaction. Morphology and arrangement of collagen fibers were observed on Masson's trichrome staining of buccal gingival tissues of experimental and control teeth. Results: SFN reduced the amount and percentage of relapse of orthodontic rotation. It also decreased the gene expression of lysyl oxidase and increased the gene expression of matrix metalloproteinase (MMP) 1 and MMP 12, compared with DMSO control subjects. Histologically, collagen fiber bundles were arranged irregularly and were not well connected in the SFN-treated group, whereas the fibers extended in parallel and perpendicular directions toward the gingiva and alveolar bone in a more regular and well-ordered arrangement in the DMSO-treated group. Conclusions: Our findings demonstrated that SFN treatment may be a promising pharmacologic approach to prevent orthodontic rotational relapse caused by increased gingival elasticity of rotated teeth in beagle dogs.
Files in This Item:
T202005321.pdf Download
DOI
10.4041/kjod.2020.50.6.391
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ju Young(김주영)
Kim, Jin(김진)
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
Cha, Jung Yul(차정열)
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
Hwang, Chung Ju(황충주) ORCID logo https://orcid.org/0000-0003-3024-4551
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180794
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