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Sclerotic changes of cavernous hemangioma in the cirrhotic liver: long-term follow-up using dynamic contrast-enhanced computed tomography

Authors
 Nari Shin  ;  Ji Ae Choi  ;  Jeong Min Choi  ;  Eun-Suk Cho  ;  Joo Hee Kim  ;  Jae-Joon Chung  ;  Jeong-Sik Yu 
Citation
 RADIOLOGIA MEDICA, Vol.125(12) : 1225-1232, 2020-12 
Journal Title
 RADIOLOGIA MEDICA 
ISSN
 0033-8362 
Issue Date
2020-12
MeSH
Analysis of Variance ; Contrast Media* ; Data Analysis ; Disease Progression ; Female ; Follow-Up Studies ; Hemangioma, Cavernous / diagnostic imaging* ; Hemangioma, Cavernous / pathology ; Humans ; Liver / diagnostic imaging* ; Liver / pathology ; Liver Cirrhosis / diagnostic imaging* ; Liver Cirrhosis / pathology ; Liver Neoplasms / diagnostic imaging* ; Liver Neoplasms / pathology ; Logistic Models ; Male ; Middle Aged ; Multidetector Computed Tomography / methods* ; Observer Variation ; Radiographic Image Enhancement ; Sclerosis ; Time Factors ; Tumor Burden
Keywords
Cirrhosis ; Computed tomography ; Hemangioma ; Liver
Abstract
Purpose: To determine the intra- and extralesional factors that predict sclerotic degeneration of hepatic hemangiomas in the cirrhotic liver on long-term follow-up computed tomography (CT) examinations. Materials and methods: Fifty-seven hepatic hemangiomas (> 5 mm in diameter) in 41 cirrhotic patients; recruited over a 5-year period (January 2005-December 2009); were subjected to CT to determine which factors predict sclerotic contraction or degeneration in hemangiomas. Prior and follow-up CT examinations (from 2000 to 2018) were included to observe time-related changes. The patients' gender; age; cause of cirrhosis; progression of background liver cirrhosis; lesion size/location/contrast enhancement pattern; and serum aspartate transaminase to platelet ratio index were correlated with sclerotic changes of each lesion. Results: According to the dynamic CT features; 36 of 57 (63%) hemangiomas were determined to have sclerotic changes during the follow-up period (1.1-14.4 years; median: 7.8 years); including 28 lesions (49%) reduced by ≥ 20% in diameter. In univariate analysis; age (p = 0.047) and morphological progression of background cirrhosis (p = 0.013) were significantly related to sclerotic change of hemangiomas. In the logistic regression analysis; only morphological progression of background liver cirrhosis independently predicted sclerotic change (odds ratio: 4.88; p = 0.007). With the exception of exophytic location free from size reduction (p = 0.023 in multivariate analysis); no other analyzed factors were significantly correlated with sclerotic changes. Conclusion: Overall; sclerotic changes of hepatic cavernous hemangioma followed the morphological progression of background liver cirrhosis; while exophytic lesions tended to be free of size reduction.
Full Text
https://link.springer.com/article/10.1007%2Fs11547-020-01221-y
DOI
10.1007/s11547-020-01221-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
Cho, Eun Suk(조은석)
Choi, Jiae(최지애) ORCID logo https://orcid.org/0000-0003-3191-9469
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180749
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