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Cochlin-cleaved LCCL is a dual-armed regulator of the innate immune response in the cochlea during inflammation

 Hyeong-Jun Rhyu  ;  Seong Hoon Bae  ;  Jinsei Jung  ;  Young-Min Hyun 
 BMB REPORTS, Vol.53(9) : 449-452, 2020-09 
Journal Title
Issue Date
The inner ear is a complex and delicate structure composed of the cochlea and the vestibular system. To maintain normal auditory function, strict homeostasis of the inner ear is needed. A proper immune response against infection, thus, is crucial. Also, since excessive immune reaction can easily damage the normal architecture within the inner ear, the immune response should be fine regulated. The exact mechanism how the inner ear's immune response, specifically the innate immunity, is regulated was unknown. Recently, we reported a protein selectively localized in the inner ear during bacterial infection, named cochlin, as a possible mediator of such regulation. In this review, the immunological function of cochlin and the mechanism behind its role within inner ear immunity is summarized. Cochlin regulates innate immunity by physically entrapping pathogens within scala tympani and recruiting innate immune cells. Such mechanism enables efficient removal of pathogen while preserving the normal inner ear structure from inflammatory damage.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Bae, Seong Hoon(배성훈)
Jung, Jinsei(정진세) ORCID logo https://orcid.org/0000-0003-1906-6969
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
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