Cited 21 times in
Chemical Controllable Gene Drive in Drosophila
DC Field | Value | Language |
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dc.contributor.author | 김형범 | - |
dc.contributor.author | 문석준 | - |
dc.contributor.author | 박경수 | - |
dc.contributor.author | 이준원 | - |
dc.contributor.author | 채동우 | - |
dc.date.accessioned | 2020-12-01T17:21:23Z | - |
dc.date.available | 2020-12-01T17:21:23Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180230 | - |
dc.description.abstract | Gene drive systems that propagate transgenes via super-Mendelian inheritance can potentially control insect-borne diseases and agricultural pests. However, concerns have been raised regarding unforeseen ecological consequences, and methods that prevent undesirable gene drive effects have been proposed. Here, we report a chemical-induced control of gene drive. We prepared a CRISPR-based gene drive system that can be removed by a site-specific recombinase, Rippase, the expression of which is induced by the chemical RU486 in fruit flies. Exposure of fruit flies to RU486 resulted in 7-12% removal of gene drive elements at each generation, leading to a significant reduction in gene drive-fly propagation. Mathematical modeling and simulation suggest that our system offers several advantages over a previously reported gene drive control system. Our chemical control system can provide a proof-of-principle for the reversible control of gene drive effects depending on ecological status and human needs. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | ACS SYNTHETIC BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Chemical Controllable Gene Drive in Drosophila | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Dongwoo Chae | - |
dc.contributor.googleauthor | Junwon Lee | - |
dc.contributor.googleauthor | Nayoung Lee | - |
dc.contributor.googleauthor | Kyungsoo Park | - |
dc.contributor.googleauthor | Seok Jun Moon | - |
dc.contributor.googleauthor | Hyongbum H Kim | - |
dc.identifier.doi | 10.1021/acssynbio.0c00117 | - |
dc.contributor.localId | A01148 | - |
dc.contributor.localId | A01358 | - |
dc.contributor.localId | A01422 | - |
dc.contributor.localId | A03179 | - |
dc.contributor.localId | A04014 | - |
dc.relation.journalcode | J03860 | - |
dc.identifier.eissn | 2161-5063 | - |
dc.identifier.pmid | 32786353 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acssynbio.0c00117 | - |
dc.subject.keyword | CRISPR-Cas9 system | - |
dc.subject.keyword | Rippase | - |
dc.subject.keyword | gene drive | - |
dc.subject.keyword | mutagenic chain reaction | - |
dc.subject.keyword | population genetics | - |
dc.contributor.alternativeName | Kim, Hyongbum | - |
dc.contributor.affiliatedAuthor | 김형범 | - |
dc.contributor.affiliatedAuthor | 문석준 | - |
dc.contributor.affiliatedAuthor | 박경수 | - |
dc.contributor.affiliatedAuthor | 이준원 | - |
dc.contributor.affiliatedAuthor | 채동우 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2362 | - |
dc.citation.endPage | 2377 | - |
dc.identifier.bibliographicCitation | ACS SYNTHETIC BIOLOGY, Vol.9(9) : 2362-2377, 2020-07 | - |
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