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Determining the optimal timing of screening spinal cord ultrasonography to detect filum terminale lipoma in infants

 Salman S Albakheet  ;  Haesung Yoon  ;  Mi-Jung Lee  ;  Myung-Joon Kim  ;  Eun-Kyung Park  ;  Kyu-Won Shim  ;  Dong-Seok Kim  ;  Ho Sun Eun  ;  Kyunghwa Han  ;  Hyun Joo Shin 
 ULTRASONOGRAPHY, Vol.39(4) : 367-375, 2020-10 
Journal Title
Issue Date
Cauda equina ; Infants ; Retrospective studies ; Spinal cord ; Ultrasonography
Purpose: The purpose of this study was to identify the optimal timing for screening spinal cord ultrasonography (US) to detect filum terminale lipoma in infants. Methods: We retrospectively reviewed infants (<12 months old) who underwent repeated spinal cord US between April 2011 and January 2019. We excluded infants if they only had one US examination, or if they had lesions other than filum terminale lipoma. Infants with filum terminale lipoma on magnetic resonance imaging were included in the lipoma group and the others in the control group. A linear mixed model was used to assess differences in the growth pattern of filum terminale thickness by age and group. The cutoff thickness on US and its diagnostic performance were assessed according to age. Results: Among 442 infants with 901 US examinations, 46 were included in the lipoma group and 58 in the control group. Sixty-seven infants had unmeasurable filum terminale thickness on initial US, including 55 neonates (82.1%) before 1 month of age. The lipoma group had significantly greater filum terminale thickness than the control group (P<0.001). Thickness increased with age in the lipoma group (P=0.027). The sensitivity of US was 87.5% and the area under the receiver operating characteristic curve was 0.949 (95% confidence interval, 0.849 to 0.991) with a cutoff value of 1.1 mm in 4- to 6-month-old infants. Conclusion: Screening spinal cord US could effectively diagnose filum terminale lipoma in 4- to 6-month-old infants with a cutoff thickness of 1.1 mm. Spinal cord US can be used to screen young infants with intraspinal abnormalities.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Kim, Myung Joon(김명준) ORCID logo https://orcid.org/0000-0002-4608-0275
Park, Eun Kyung(박은경)
Shin, Hyun Joo(신현주) ORCID logo https://orcid.org/0000-0002-7462-2609
Shim, Kyu Won(심규원) ORCID logo https://orcid.org/0000-0002-9441-7354
Yoon, Haesung(윤혜성) ORCID logo https://orcid.org/0000-0003-0581-8656
Eun, Ho Seon(은호선) ORCID logo https://orcid.org/0000-0001-7212-0341
Lee, Mi-Jung(이미정) ORCID logo https://orcid.org/0000-0003-3244-9171
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