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Deficiencies of Homer2 and Homer3 accelerate aging-dependent bone loss in mice

Authors
 Jung Yun Kang  ;  Namju Kang  ;  Dong Min Shin  ;  Yu-Mi Yang 
Citation
 International Journal of Oral Biology, Vol.45(3) : 126-133, 2020-09 
Journal Title
 International Journal of Oral Biology 
ISSN
 1226-7155 
Issue Date
2020-09
Abstract
Homer proteins are scaffold proteins that regulate calcium (Ca2+) signaling by modulating the activity of multiple Ca2+ signaling proteins. In our previous report, Homer2 and Homer3 regulated NFATc1 function through its interaction with calcineurin, which then acted to regulate receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and bone metabolism. However, to date, the role of Homers in osteoclastogenesis remains unknown. In this study, we investigated the roles of Homer2 and Homer3 in aging-dependent bone remodeling. Deletion of Homer2 /Homer3 (Homer2/3 DKO) markedly decreased the bone density of the femur. The decrease in bone density was not seen in mice with Homer2 (Homer2−/−) and Homer3 (Homer3−/−) deletion. Moreover, RANKL treatment of bone marrow-derived monocytes/macrophages in Homer2/3 DKO mice significantly increased the formation of multinucleated cells and resorption areas. Finally, Homer2/3 DKO mice decreased bone density in an aging-dependent manner. These findings suggest a novel potent mode of bone homeostasis regulation through osteoclasts differentiation during aging by Homer proteins, specifically Homer2 and Homer3.
Files in This Item:
T202003990.pdf Download
DOI
10.11620/IJOB.2020.45.3.126
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Dong Min(신동민) ORCID logo https://orcid.org/0000-0001-6042-0435
Yang, Yu Mi(양유미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180090
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