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Deficiencies of Homer2 and Homer3 accelerate aging-dependent bone loss in mice
DC Field | Value | Language |
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dc.contributor.author | 신동민 | - |
dc.contributor.author | 양유미 | - |
dc.date.accessioned | 2020-12-01T17:01:39Z | - |
dc.date.available | 2020-12-01T17:01:39Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180090 | - |
dc.description.abstract | Homer proteins are scaffold proteins that regulate calcium (Ca2+) signaling by modulating the activity of multiple Ca2+ signaling proteins. In our previous report, Homer2 and Homer3 regulated NFATc1 function through its interaction with calcineurin, which then acted to regulate receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and bone metabolism. However, to date, the role of Homers in osteoclastogenesis remains unknown. In this study, we investigated the roles of Homer2 and Homer3 in aging-dependent bone remodeling. Deletion of Homer2 /Homer3 (Homer2/3 DKO) markedly decreased the bone density of the femur. The decrease in bone density was not seen in mice with Homer2 (Homer2−/−) and Homer3 (Homer3−/−) deletion. Moreover, RANKL treatment of bone marrow-derived monocytes/macrophages in Homer2/3 DKO mice significantly increased the formation of multinucleated cells and resorption areas. Finally, Homer2/3 DKO mice decreased bone density in an aging-dependent manner. These findings suggest a novel potent mode of bone homeostasis regulation through osteoclasts differentiation during aging by Homer proteins, specifically Homer2 and Homer3. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Harn Rim Won Printing Co. | - |
dc.relation.isPartOf | International Journal of Oral Biology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Deficiencies of Homer2 and Homer3 accelerate aging-dependent bone loss in mice | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Jung Yun Kang | - |
dc.contributor.googleauthor | Namju Kang | - |
dc.contributor.googleauthor | Dong Min Shin | - |
dc.contributor.googleauthor | Yu-Mi Yang | - |
dc.identifier.doi | 10.11620/IJOB.2020.45.3.126 | - |
dc.contributor.localId | A02091 | - |
dc.contributor.localId | A05148 | - |
dc.relation.journalcode | J01144 | - |
dc.contributor.alternativeName | Shin, Dong Min | - |
dc.contributor.affiliatedAuthor | 신동민 | - |
dc.contributor.affiliatedAuthor | 양유미 | - |
dc.citation.volume | 45 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 126 | - |
dc.citation.endPage | 133 | - |
dc.identifier.bibliographicCitation | International Journal of Oral Biology, Vol.45(3) : 126-133, 2020-09 | - |
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