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Preoperative Magnetic Resonance Imaging Features Associated with Positive Resection Margins in Patients with Invasive Lobular Carcinoma

Authors
 Jiyoung Yoon  ;  Eun Kyung Kim  ;  Min Jung Kim  ;  Hee Jung Moon  ;  Jung Hyun Yoon  ;  Vivian Y Park 
Citation
 KOREAN JOURNAL OF RADIOLOGY, Vol.21(8) : 946-954, 2020-08 
Journal Title
 KOREAN JOURNAL OF RADIOLOGY 
ISSN
 1229-6929 
Issue Date
2020-08
MeSH
Adult ; Aged ; Breast Neoplasms / diagnostic imaging* ; Breast Neoplasms / pathology ; Breast Neoplasms / surgery ; Carcinoma, Ductal, Breast / diagnostic imaging ; Carcinoma, Ductal, Breast / pathology ; Carcinoma, Ductal, Breast / surgery ; Carcinoma, Intraductal, Noninfiltrating / diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating / pathology ; Carcinoma, Intraductal, Noninfiltrating / surgery ; Carcinoma, Lobular / diagnostic imaging* ; Carcinoma, Lobular / pathology ; Carcinoma, Lobular / surgery ; Female ; Humans ; Lymphatic Metastasis / pathology ; Magnetic Resonance Imaging / methods ; Margins of Excision* ; Mastectomy, Segmental / methods* ; Middle Aged ; Retrospective Studies
Keywords
Breast ; Carcinoma, lobular ; Magnetic resonance imaging ; Margins of excision
Abstract
Objective: To investigate preoperative magnetic resonance imaging (MRI) findings associated with resection margin status in patients with invasive lobular carcinoma (ILC) who underwent breast-conserving surgery. Materials and methods: One hundred and one patients with ILC who underwent preoperative MRI were included. MRI (tumor size, multifocality, type of enhancing lesion, distribution of non-mass enhancement [NME], and degree of background parenchymal enhancement) and clinicopathological features (age, pathologic tumor size, presence of ductal carcinoma in situ [DCIS] or lobular carcinoma in situ, presence of lymph node metastases, and estrogen receptor/progesterone receptor/human epidermal growth factor receptor type 2 status) were analyzed. A positive resection margin was defined as the presence of invasive cancer or DCIS at the inked surface. Logistic regression analysis was performed to determine pre- and postoperative variables associated with positive resection margins. Results: Among the 101 patients, 21 (20.8%) showed positive resection margins. In the univariable analysis, NME, multifocality, axillary lymph node metastasis, and pathologic tumor size were associated with positive resection margins. With respect to preoperative MRI findings, multifocality (odds ratio [OR] = 3.977, p = 0.009) and NME (OR = 2.741, p = 0.063) were associated with positive resection margins in the multivariable analysis, although NME showed borderline significance. Conclusion: In patients with ILC, multifocality and the presence of NME on preoperative breast MRI were associated with positive resection margins.
Files in This Item:
T202003651.pdf Download
DOI
10.3348/kjr.2019.0674
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Park, Vivian Youngjean(박영진) ORCID logo https://orcid.org/0000-0002-5135-4058
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
Yoon, Jiyoung(윤지영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180029
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