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Robust performance of deep learning for distinguishing glioblastoma from single brain metastasis using radiomic features: model development and validation

Authors
 Sohi Bae  ;  Chansik An  ;  Sung Soo Ahn  ;  Hwiyoung Kim  ;  Kyunghwa Han  ;  Sang Wook Kim  ;  Ji Eun Park  ;  Ho Sung Kim  ;  Seung-Koo Lee 
Citation
 SCIENTIFIC REPORTS, Vol.10(1) : 12110, 2020-07 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2020-07
Abstract
We evaluated the diagnostic performance and generalizability of traditional machine learning and deep learning models for distinguishing glioblastoma from single brain metastasis using radiomics. The training and external validation cohorts comprised 166 (109 glioblastomas and 57 metastases) and 82 (50 glioblastomas and 32 metastases) patients, respectively. Two-hundred-and-sixty-five radiomic features were extracted from semiautomatically segmented regions on contrast-enhancing and peritumoral T2 hyperintense masks and used as input data. For each of a deep neural network (DNN) and seven traditional machine learning classifiers combined with one of five feature selection methods, hyperparameters were optimized through tenfold cross-validation in the training cohort. The diagnostic performance of the optimized models and two neuroradiologists was tested in the validation cohort for distinguishing glioblastoma from metastasis. In the external validation, DNN showed the highest diagnostic performance, with an area under receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy of 0.956 (95% confidence interval [CI], 0.918-0.990), 90.6% (95% CI, 80.5-100), 88.0% (95% CI, 79.0-97.0), and 89.0% (95% CI, 82.3-95.8), respectively, compared to the best-performing traditional machine learning model (adaptive boosting combined with tree-based feature selection; AUC, 0.890 (95% CI, 0.823-0.947)) and human readers (AUC, 0.774 [95% CI, 0.685-0.852] and 0.904 [95% CI, 0.852-0.951]). The results demonstrated deep learning using radiomic features can be useful for distinguishing glioblastoma from metastasis with good generalizability.
Files in This Item:
T202003649.pdf Download
DOI
10.1038/s41598-020-68980-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hwiyoung(김휘영)
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180027
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