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Association between exposure to polycyclic aromatic hydrocarbons and brain cortical thinning: The Environmental Pollution-Induced Neurological EFfects (EPINEF) study

Authors
 Jaelim Cho  ;  Jungwoo Sohn  ;  Juhwan Noh  ;  Heeseon Jang  ;  Woojin Kim  ;  Seong-Kyung Cho  ;  Hwasun Seo  ;  Gayoung Seo  ;  Seung-Koo Lee  ;  Young Noh  ;  Seongho Seo  ;  Sang-Baek Koh  ;  Sung Soo Oh  ;  Hee Jin Kim  ;  Sang Won Seo  ;  Dae-Seock Shin  ;  Nakyoung Kim  ;  Ho Hyun Kim  ;  Jung Il Lee  ;  Sun Young Kim  ;  Changsoo Kim 
Citation
 SCIENCE OF THE TOTAL ENVIRONMENT, Vol.737 : 140097, 2020-10 
Journal Title
 SCIENCE OF THE TOTAL ENVIRONMENT 
ISSN
 0048-9697 
Issue Date
2020-10
MeSH
Adult ; Biomarkers ; Brain ; Child ; Environmental Exposure / analysis ; Environmental Pollution ; Female ; Humans ; Male ; Polycyclic Aromatic Hydrocarbons / analysis* ; Republic of Korea
Keywords
Brain cortical thickness ; Cognitive function ; Neuroimaging ; Neurotoxicity ; Polycyclic aromatic hydrocarbon
Abstract
Background: Although some studies have suggested that exposure to polycyclic aromatic hydrocarbons (PAHs) induces neurodevelopmental disturbances in children and neurodegeneration in animals, the neurotoxic effect of PAH exposure is unclear in adults. The aim was to examine the associations of PAH exposure with brain structure and neuropsychological function in adults without known neurological diseases. Methods: This study included 421 men and 528 women dwelling in four cities in the Republic of Korea. Urinary concentrations of four PAH metabolites (1-hydroxypyrene, 2-naphthol, 1-hydroxyphenanthrene, and 2-hydroxyfluorene) were obtained. Participants underwent brain 3 T magnetic resonance imaging and neuropsychological tests. Cortical thickness and volume were estimated using the region-of-interest method. Separate generalized linear models were constructed for each sex, adjusting for age, years of education, cohabitation status, income, tobacco use, alcohol consumption, and vascular risk factors. Results: The mean (standard deviation) age was 68.3 (6.6) years in men and 66.4 (6.1) years in women. In men, those in quartile 4 (versus quartile 1, the lowest) of urinary 2-naphthol concentration had cortical thinning in the global (β = -0.03, P = .02), parietal (β = -0.04, P = .01), temporal (β = -0.06, P < .001), and insular lobes (β = -0.05, P = .02). Higher quartiles of urinary 2-naphthol concentration were associated with cortical thinning in the global (P = .01), parietal (P = .004), temporal (P < .001), and insular lobes (P = .01). In women, those in quartile 4 (versus quartile 1) of urinary 1-hydroxypyrene concentration had cortical thinning in the frontal (β = -0.03, P = .006) and parietal lobes (β = -0.03, P = .003). Higher quartiles of urinary 1-hydroxypyrene concentration were associated with cortical thinning in the frontal (P = .006) and parietal lobes (P = .001). In both sexes, verbal learning and memory scores significantly declined with an increase in quartile of urinary 1-hydroxypyrene concentration. Conclusions: PAH exposure was associated with cortical thinning and decline in verbal learning and memory function in cognitively healthy adults. This suggests PAHs as an environmental risk factor for neurodegeneration.
Full Text
https://www.sciencedirect.com/science/article/pii/S0048969720336172
DOI
10.1016/j.scitotenv.2020.140097
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Cho, Jae Lim(조재림)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179959
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