5 8

Cited 0 times in

Association between the Thigh Muscle and Insulin Resistance According to Body Mass Index in Middle-Aged Korean Adults

 Ji Eun Heo  ;  Jee Seon Shim  ;  Hokyou Lee  ;  Hyeon Chang Kim 
 DIABETES & METABOLISM JOURNAL, Vol.44(3) : 446-457, 2020-06 
Journal Title
Issue Date
Body composition ; Insulin resistance ; Muscles ; Sarcopenia ; Tomography, X-ray computed
Background: We examined the associations between thigh muscle area (TMA) and insulin resistance (IR) according to body mass index (BMI) in middle-aged Korean general population. Methods: TMA was measured using quantitative computed tomography and corrected by body weight (TMA/Wt) in 1,263 men, 788 premenopausal women, and 1,476 postmenopausal women all aged 30 to 64 years. The tertiles of TMA/Wt were calculated separately for men and for premenopausal and postmenopausal women. Homeostatic model assessment for insulin resistance (HOMA-IR) was performed using fasting blood glucose and insulin levels, and increased IR was defined according to sex-specific, top quartiles of HOMA-IR. Associations between the TMA/Wt tertiles and increased IR according to the BMI categories (<25 and ≥25 kg/m²) were assessed using multivariable logistic regression analysis. Results: In men with higher BMIs, but not in those with lower BMIs, the presence of an increased IR had significantly higher odds ratios in the lower TMA/Wt tertiles, even after adjustment for visceral fat area. However, in premenopausal and postmenopausal women, there was no significant inverse association between TMA/Wt tertiles and increased IR, regardless of BMI category. Conclusion: Our findings suggest that the thigh muscle is inversely associated with IR in men, particularly in those with higher BMIs.
Files in This Item:
T202002627.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Shim, Jee Seon(심지선) ORCID logo https://orcid.org/0000-0002-8671-3153
Lee, Hokyou(이호규) ORCID logo https://orcid.org/0000-0002-5034-8422
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.