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Cited 4 times in

Factors for Enhancement of Intracranial Atherosclerosis in High Resolution Vessel Wall MRI in Ischemic Stroke Patients

DC Field Value Language
dc.contributor.author우나은-
dc.contributor.author남효석-
dc.contributor.author김영대-
dc.contributor.author허지회-
dc.contributor.author이승구-
dc.contributor.author최현석-
dc.contributor.author차지훈-
dc.contributor.author안성수-
dc.contributor.author이혜선-
dc.date.accessioned2020-09-28T12:13:19Z-
dc.date.available2020-09-28T12:13:19Z-
dc.date.issued2020-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179350-
dc.description.abstractIntroduction: High resolution vessel wall MRI (VW-MRI) has enabled to characterize intracranial atherosclerosis (ICAS). We studied to identify the factors for enhancement of ICAS in VW-MRI in patients with acute ischemic stroke. Methods: Consecutive patients with acute ischemic stroke or TIA who underwent VW-MRI between January 2017 and December 2017 were included. Enhancement on VW-MRI was defined as an increase in intensity on contrast-enhanced T1-weighted sequence. We compared the clinical and the radiologic findings between patients with wall enhancement and those without wall enhancement. Results: Of the 48 patients with ICAS, 28 patients revealed enhancement on VW-MRI. Patients with enhancement were more likely to have severe stenotic lesions and higher levels of total cholesterol, triglycerides, low-density cholesterol, Apo (b), and Apo (b)/Apo (a) lipoprotein ratio (p < 0.05). Multivariable analysis demonstrated that total cholesterol (OR: 5.378, 95% CI, 1.779-16.263), triglycerides (OR: 3.362, 95% CI, 1.008-11.209), low density lipoprotein cholesterol (OR: 4.226, 95% CI, 1.264-14.126), Apo (b) lipoprotein (OR: 3639.641, 95% CI, 17.854-741954.943) levels, and Apo (b)/Apo (a) lipoprotein ratio (OR, 65.514; 95% CI, 1.131-3680.239) were independently associated with enhancement of ICAS. High-density lipoprotein cholesterol and Apo (a) lipoprotein levels were not significantly different between the patients with wall enhancement and those without wall enhancement. Conclusions: The presence and severity of enhancement of ICAS was significantly associated with dyslipidemic conditions. These results suggest that strict lipid modification should be achieved for the management of ICAS.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleFactors for Enhancement of Intracranial Atherosclerosis in High Resolution Vessel Wall MRI in Ischemic Stroke Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorNa-Eun Woo-
dc.contributor.googleauthorHan Kyu Na-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorJin Kyo Choi-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorHyun Seok Choi-
dc.contributor.googleauthorSeung-Koo Lee-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJihoon Cha-
dc.contributor.googleauthorYoung Dae Kim-
dc.identifier.doi10.3389/fneur.2020.00580-
dc.contributor.localIdA05667-
dc.contributor.localIdA01273-
dc.contributor.localIdA00702-
dc.contributor.localIdA04369-
dc.contributor.localIdA02912-
dc.contributor.localIdA04209-
dc.contributor.localIdA05808-
dc.contributor.localIdA02234-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ02996-
dc.identifier.eissn1664-2295-
dc.identifier.pmid32676051-
dc.subject.keywordatherosclerosis-
dc.subject.keyworddyslipidemia-
dc.subject.keywordhigh resolution MRI-
dc.subject.keywordstroke-
dc.subject.keywordvessel wall MRI-
dc.contributor.alternativeNameWoo, Naeun-
dc.contributor.affiliatedAuthor우나은-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor허지회-
dc.contributor.affiliatedAuthor이승구-
dc.contributor.affiliatedAuthor최현석-
dc.contributor.affiliatedAuthor차지훈-
dc.contributor.affiliatedAuthor안성수-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume11-
dc.citation.startPage580-
dc.identifier.bibliographicCitationFRONTIERS IN NEUROLOGY, Vol.11 : 580, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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