7 10

Cited 0 times in

Bone marrow fat change in pediatric patients with non-alcoholic fatty liver disease

Authors
 Salman S Albakheet  ;  Haesung Yoon  ;  Hyun Joo Shin  ;  Hong Koh  ;  Seung Kim  ;  Mi-Jung Lee 
Citation
 PLOS ONE, Vol.15(6) : e0234096, 2020-06 
Journal Title
 PLOS ONE 
Issue Date
2020-06
MeSH
Adolescent ; Body Mass Index ; Bone Marrow / diagnostic imaging ; Child ; Female ; Humans ; Image Processing, Computer-Assisted ; Lipids / analysis ; Liver / diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Non-alcoholic Fatty Liver Disease / metabolism ; Non-alcoholic Fatty Liver Disease / pathology* ; Paraspinal Muscles / diagnostic imaging ; Retrospective Studies
Abstract
Objectives: To investigate changes of fat in bone marrow (BM) and paraspinal muscle (PSM) associated with the degree of fatty liver in pediatric patients with non-alcoholic fatty liver disease (NAFLD) in consideration of age and body mass index (BMI). Methods: Hepatic fat, BM fat, and PSM fat from proton density fat fraction of liver MRI between June 2015 and April 2019 were quantitatively evaluated on axial images of the fat map at the mid-level of T11-L2 vertebral bodies for BM fat and at the mid-level of L2 for PSM fat. Age, height, and weight at the time of MRI were recorded and BMI was calculated. Correlation analysis was performed. Results: A total of 147 patients (114 male) were included with a mean age of 13.3 ± 2.9 years (range 7-18 years). The mean fat fractions were 24.3 ± 13.0% (2-53%) in liver, 37.4 ± 8.6% (17.3-56%) in vertebral BM, and 2.7 ± 1.1% (1.0-6.9%) in PSM. Age, height, weight, and BMI were not correlated with liver fat or BM fat. However, weight (ρ = 0.174, p = 0.035) and BMI (ρ = 0.247, p = 0.003) were positively correlated with PSM fat. Liver fat showed positive correlation with BM fat when adjusting age and BMI (ρ = 0.309, p<0.001), but not with PSM fat. Conclusions: BM fat positively correlates with liver fat, but not with age or BMI in pediatric NAFLD patients.
Files in This Item:
T202002321.pdf Download
DOI
10.1371/journal.pone.0234096
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
Kim, Seung(김승) ORCID logo https://orcid.org/0000-0003-4373-9828
Shin, Hyun Joo(신현주) ORCID logo https://orcid.org/0000-0002-7462-2609
Yoon, Haesung(윤혜성) ORCID logo https://orcid.org/0000-0003-0581-8656
Lee, Mi-Jung(이미정) ORCID logo https://orcid.org/0000-0003-3244-9171
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179328
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links