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Diagnostic performances and unnecessary US-FNA rates of various TIRADS after application of equal size thresholds

DC FieldValueLanguage
dc.contributor.author윤정현-
dc.contributor.author윤지영-
dc.contributor.author박영진-
dc.contributor.author문희정-
dc.contributor.author곽진영-
dc.contributor.author김은경-
dc.contributor.author이혜선-
dc.date.accessioned2020-09-28T11:59:02Z-
dc.date.available2020-09-28T11:59:02Z-
dc.date.issued2020-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179308-
dc.description.abstractWe compared the diagnostic performances and unnecessary FNA rates of several guidelines and modified versions using the size threshold of the ACR TIRADS. Our Institutional Review Board approved this retrospective study and waived the requirement for informed consent and all methods were performed in accordance with the Declaration of Helsinki. A total of 1,384 thyroid nodules in 1,301 patients with definitive cytopathologic findings were included. US categories were assigned according to each guideline. We applied the size threshold suggested by the ACR TIRADS for FNA to the Kwak, ATA and EU guidelines and defined these modified guidelines as the modified Kwak (mKwak), modified ATA (mATA) and modified EU (mEU) guidelines. Diagnostic performances and unnecessary FNA rates of all guidelines were evaluated. Of 1,384 thyroid nodules, 291 (21%) were malignant. Among the original guidelines, the ACR TIRADS had the highest specificity, accuracy, LR and AUC (62.2%, 66%, 2.128 and 0.713). The mKwak, mATA and mEU guidelines had higher specificity, accuracy, LR and AUC (P < 0.001 for all), and fewer unnecessary FNAs, compared with their original guidelines. Among all original and modified guidelines, the mKwak guideline had the highest specificity, accuracy, LR and AUC (64%, 68.6%, 2.389 and 0.75). The unnecessary FNA rate was the lowest with the mKwak guideline (61.1%). The highest sensitivity was observed with the ATA guideline (98.6%). After incorporating the size threshold of the ACR TIRADS to other TIRADS, all guidelines showed higher diagnostic accuracy and lower unnecessary FNA rates than their original versions. The mKwak guideline showed the best diagnostic performances.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDiagnostic performances and unnecessary US-FNA rates of various TIRADS after application of equal size thresholds-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorSun Huh-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJiyoung Yoon-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorVivian Youngjean Park-
dc.contributor.googleauthorJin Young Kwak-
dc.identifier.doi10.1038/s41598-020-67543-z-
dc.contributor.localIdA02595-
dc.contributor.localIdA05730-
dc.contributor.localIdA05730-
dc.contributor.localIdA01572-
dc.contributor.localIdA01572-
dc.contributor.localIdA01397-
dc.contributor.localIdA01397-
dc.contributor.localIdA00182-
dc.contributor.localIdA00182-
dc.contributor.localIdA00801-
dc.contributor.localIdA00801-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid32606433-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.affiliatedAuthor윤정현-
dc.contributor.affiliatedAuthor윤지영-
dc.contributor.affiliatedAuthor윤지영-
dc.contributor.affiliatedAuthor박영진-
dc.contributor.affiliatedAuthor박영진-
dc.contributor.affiliatedAuthor문희정-
dc.contributor.affiliatedAuthor문희정-
dc.contributor.affiliatedAuthor곽진영-
dc.contributor.affiliatedAuthor곽진영-
dc.contributor.affiliatedAuthor김은경-
dc.contributor.affiliatedAuthor김은경-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage10632-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.10(1) : 10632, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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