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Outcome of Stroke Patients with Cancer and Nonbacterial Thrombotic Endocarditis

DC FieldValueLanguage
dc.contributor.author유준상-
dc.contributor.author남효석-
dc.contributor.author김영대-
dc.contributor.author허지회-
dc.contributor.author박형종-
dc.contributor.author이혜선-
dc.date.accessioned2020-09-28T11:40:15Z-
dc.date.available2020-09-28T11:40:15Z-
dc.date.issued2020-05-
dc.identifier.issn2287-6391-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179241-
dc.description.abstractBackground and purpose: Nonbacterial thrombotic endocarditis (NBTE) is a cause of stroke in cancer. However, clinical characteristics and outcomes in stroke patients with cancer-associated NBTE are not well known. Methods: We included consecutive patients with stroke and active cancer over a 9-year period who underwent echocardiography. We retrospectively compared clinical characteristics and presence of metastasis between patients with NBTE, those with cryptogenic etiologies, and those with determined etiologies. We also investigated mortality and stroke events during the 6-month follow-up. Results: Among the 245 patients, 20 had NBTE, 96 had cryptogenic etiologies, and 129 had determined etiologies. Metastasis was seen in all 20 patients (100%) with NBTE, 69.8% in patients with cryptogenic etiology, and 48.8% in patients with or determined etiology. During the 6-month follow-up, 127 patients (51.8%) developed stroke and/or died (death in 110 [44.9%] and stroke events in 55 [22.4%]). Patients with NBTE showed significantly higher mortality (80%) and stroke occurrence (50%) than those with cryptogenic etiologies (mortality 54.2%, stroke 25.0%, log-rank P=0.006) and determined etiologies (mortality 32.6%, stroke 16.3%, log-rank P<0.001). In a multivariate Cox proportional hazard analysis, the presence of NBTE was independently associated with composite outcomes of mortality and stroke events (hazard ratio, 1.941; 95% confidence interval, 1.052 to 3.690). Conclusions: NBTE should be suspected as a potential cause of stroke in patients with metastatic cancer. Patients with NBTE have a high risk of recurrent stroke and mortality. Future studies are necessary to determine strategies to reduce stroke recurrence in patients with NBTE.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Stroke Society-
dc.relation.isPartOfJOURNAL OF STROKE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleOutcome of Stroke Patients with Cancer and Nonbacterial Thrombotic Endocarditis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorJoonsang Yoo-
dc.contributor.googleauthorJin Kyo Choi-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorHyungjong Park-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJi Hoe Heo-
dc.identifier.doi10.5853/jos.2020.00619-
dc.contributor.localIdA02513-
dc.contributor.localIdA01273-
dc.contributor.localIdA01273-
dc.contributor.localIdA00702-
dc.contributor.localIdA00702-
dc.contributor.localIdA04369-
dc.contributor.localIdA04369-
dc.contributor.localIdA05600-
dc.contributor.localIdA05600-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ01758-
dc.identifier.eissn2287-6405-
dc.identifier.pmid32635688-
dc.subject.keywordMetastasis-
dc.subject.keywordMortality-
dc.subject.keywordNeoplasms-
dc.subject.keywordNonbacterial thrombotic endocarditis-
dc.subject.keywordStroke-
dc.contributor.alternativeNameYoo, Joon Sang-
dc.contributor.affiliatedAuthor유준상-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor허지회-
dc.contributor.affiliatedAuthor허지회-
dc.contributor.affiliatedAuthor박형종-
dc.contributor.affiliatedAuthor박형종-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume22-
dc.citation.number2-
dc.citation.startPage245-
dc.citation.endPage253-
dc.identifier.bibliographicCitationJOURNAL OF STROKE, Vol.22(2) : 245-253, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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