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Association Between Prostate Cancer and 25-Hydroxyvitamin D2 Levels: National Health and Nutrition Examination Survey 2007−2008 Results

Authors
 Jee Soo Park  ;  Won Sik Jang  ;  Sung Joon Hong  ;  Young Deuk Choi  ;  Koon Ho Rha  ;  Won Sik Ham 
Citation
 Korean Journal of Urological Oncology (대한비뇨기종양학술지), Vol.18(1) : 32-39, 2020-04 
Journal Title
 Korean Journal of Urological Oncology (대한비뇨기종양학술지) 
ISSN
 2234-4977 
Issue Date
2020-04
Keywords
Prostate cancer ; Vitamin D ; Age ; Prostate specific antigen
Abstract
Purpose: To report an association between prostate cancer and vitamin D levels among different races in a single population in the United States. Materials and Methods: We investigated whether there was an association between vitamin D level and prostate cancer in different races in the United States. We used data collected from 1,363 men during the National Health and Nutrition Examination Survey 2007–2008. Multivariate logistic regression analysis was used to evaluate the independent associations between vitamin D levels (not only 25-hydroxyvitamin D [25(OH)D], but also 25(OH)D2 and D3) and prostate cancer. Association between vitamin D levels and prostate specific antigen level was also analyzed in non-Hispanic white males without prostate cancer. Results: Older age was significantly associated with prostate cancer in all races (p<0.05), whereas vitamin D (p=0.024), especially 25(OH)D2 (p=0.027) was significantly higher only in non-Hispanic white males. There was no difference in vitamin D levels between non-Hispanic white males with a prostate specific antigen concentration >3 ng/mL and ≤3 ng/mL. Conclusions: This study revealed a positive association between vitamin D, especially 25(OH)D2, and prostate cancer only in non-Hispanic white males. And vitamin D was not associated with prostate specific antigen level causing detection bias.
Files in This Item:
T202002807.pdf Download
DOI
10.22465/kjuo.2020.18.1.32
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Park, Jee Soo(박지수) ORCID logo https://orcid.org/0000-0001-9976-6599
Jang, Won Sik(장원식) ORCID logo https://orcid.org/0000-0002-9082-0381
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Ham, Won Sik(함원식) ORCID logo https://orcid.org/0000-0003-2246-8838
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179111
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