32 37

Cited 0 times in

Differential Genotyping of Mycobacterium avium Complex and Its Implications in Clinical and Environmental Epidemiology

Authors
 Jeong-Ih Shin  ;  Sung Jae Shin  ;  Min-Kyoung Shin 
Citation
 MICROORGANISMS, Vol.8(1) : 98, 2020-01 
Journal Title
 MICROORGANISMS 
Issue Date
2020-01
Keywords
Mycobacterium avium complex (MAC) ; clinical epidemiology ; environmental epidemiology ; genotyping ; mycobacterial interspersed repetitive-unit-variable number of tandem repeats (MIRU-VNTR) ; pulsed-field gel electrophoresis (PFGE) ; repetitive element sequence-based PCR (rep-PCR) ; variable number of tandem repeats (VNTR)
Abstract
In recent decades, the incidence and prevalence of nontuberculous mycobacteria (NTM) have greatly increased, becoming a major worldwide public health problem. Among numerous NTM species, the Mycobacterium avium complex (MAC) is the most predominant species, causing disease in humans. MAC is recognized as a ubiquitous microorganism, with contaminated water and soil being established sources of infection. However, the reason for the recent increase in MAC-associated disease has not yet been fully elucidated. Furthermore, human MAC infections are associated with a variety of infection sources. To improve the determination of infection sources and epidemiology of MAC, feasible and reliable genotyping methods are required to allow for the characterization of the epidemiology and biology of MAC. In this review, we discuss genotyping methods, such as pulsed-field gel electrophoresis, a variable number of tandem repeats, mycobacterial interspersed repetitive-unit-variable number of tandem repeats, and repetitive element sequence-based PCR that have been applied to elucidate the association between the MAC genotypes and epidemiological dominance, clinical phenotypes, evolutionary process, and control measures of infection. Characterizing the association between infection sources and the epidemiology of MAC will allow for the development of novel preventive strategies for the effective control of MAC infection.
Files in This Item:
T202001790.pdf Download
DOI
10.3390/microorganisms8010098
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178973
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links