126 182

Cited 0 times in

Differential Genotyping of Mycobacterium avium Complex and Its Implications in Clinical and Environmental Epidemiology

DC Field Value Language
dc.contributor.author신성재-
dc.date.accessioned2020-09-28T00:53:23Z-
dc.date.available2020-09-28T00:53:23Z-
dc.date.issued2020-01-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178973-
dc.description.abstractIn recent decades, the incidence and prevalence of nontuberculous mycobacteria (NTM) have greatly increased, becoming a major worldwide public health problem. Among numerous NTM species, the Mycobacterium avium complex (MAC) is the most predominant species, causing disease in humans. MAC is recognized as a ubiquitous microorganism, with contaminated water and soil being established sources of infection. However, the reason for the recent increase in MAC-associated disease has not yet been fully elucidated. Furthermore, human MAC infections are associated with a variety of infection sources. To improve the determination of infection sources and epidemiology of MAC, feasible and reliable genotyping methods are required to allow for the characterization of the epidemiology and biology of MAC. In this review, we discuss genotyping methods, such as pulsed-field gel electrophoresis, a variable number of tandem repeats, mycobacterial interspersed repetitive-unit-variable number of tandem repeats, and repetitive element sequence-based PCR that have been applied to elucidate the association between the MAC genotypes and epidemiological dominance, clinical phenotypes, evolutionary process, and control measures of infection. Characterizing the association between infection sources and the epidemiology of MAC will allow for the development of novel preventive strategies for the effective control of MAC infection.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfMICROORGANISMS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDifferential Genotyping of Mycobacterium avium Complex and Its Implications in Clinical and Environmental Epidemiology-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorJeong-Ih Shin-
dc.contributor.googleauthorSung Jae Shin-
dc.contributor.googleauthorMin-Kyoung Shin-
dc.identifier.doi10.3390/microorganisms8010098-
dc.contributor.localIdA02114-
dc.relation.journalcodeJ03887-
dc.identifier.eissn2076-2607-
dc.identifier.pmid31936743-
dc.subject.keywordMycobacterium avium complex (MAC)-
dc.subject.keywordclinical epidemiology-
dc.subject.keywordenvironmental epidemiology-
dc.subject.keywordgenotyping-
dc.subject.keywordmycobacterial interspersed repetitive-unit-variable number of tandem repeats (MIRU-VNTR)-
dc.subject.keywordpulsed-field gel electrophoresis (PFGE)-
dc.subject.keywordrepetitive element sequence-based PCR (rep-PCR)-
dc.subject.keywordvariable number of tandem repeats (VNTR)-
dc.contributor.alternativeNameShin, Sung Jae-
dc.contributor.affiliatedAuthor신성재-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage98-
dc.identifier.bibliographicCitationMICROORGANISMS, Vol.8(1) : 98, 2020-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.