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Clinical value of CT/MR-US fusion imaging for radiofrequency ablation of hepatic nodules

Authors
 Jae Young Lee  ;  Byung Ihn Choi  ;  Yong Eun Chung  ;  Min Wook Kim  ;  Se Hyung Kim  ;  Joon Koo Han 
Citation
 EUROPEAN JOURNAL OF RADIOLOGY, Vol.81(9) : 2281-2289, 2012-09 
Journal Title
 EUROPEAN JOURNAL OF RADIOLOGY 
ISSN
 0720-048X 
Issue Date
2012-09
MeSH
Animals ; Carcinoma, Hepatocellular / diagnosis* ; Carcinoma, Hepatocellular / secondary ; Carcinoma, Hepatocellular / surgery* ; Catheter Ablation / methods* ; Cattle ; Diagnostic Imaging / methods ; Female ; Hepatectomy / methods* ; Humans ; Liver Neoplasms / diagnosis* ; Liver Neoplasms / secondary ; Liver Neoplasms / surgery* ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Subtraction Technique ; Surgery, Computer-Assisted / methods* ; Treatment Outcome
Abstract
Objective: The aim of this study was to determine the registration error of an ultrasound (US) fusion imaging system during an ex vivo study and its clinical value for percutaneous radiofrequency ablation (pRFA) during an in vivo study. Materials and methods: An ex vivo study was performed using 4 bovine livers and 66 sonographically invisible lead pellets. Real-time CT-US fusion imaging was applied to assist the targeting of pellets with needles in each liver; the 4 sessions were performed by either an experienced radiologist (R1, 3 sessions) or an inexperienced resident (R2, 1 session). The distance between the pellet target and needle was measured. An in vivo study was retrospectively performed with 51 nodules (42 HCCs and 9 metastases; mean diameter, 16 mm) of 37 patients. Fusion imaging was used to create a sufficient safety margin (>5 mm) during pRFA in 24 nodules (group 1), accurately target 21 nodules obscured in the US images (group 2) and precisely identify 6 nodules surrounded by similar looking nodules (group 3). Image fusion was achieved using MR and CT images in 16 and 21 patients, respectively. The reablation rate, 1-year local recurrence rate and complications were assessed. Results: In the ex vivo study, the mean target-needle distances were 2.7 mm±1.9 mm (R1) and 3.1±3.3 mm (R2) (p>0.05). In the in vivo study, the reablation rates in groups 1-3 were 13%, 19% and 0%, respectively. At 1 year, the local recurrence rate was 11.8% (6/51). In our assessment of complications, one bile duct injury was observed. Conclusion: US fusion imaging system has an acceptable registration error and can be an efficacious tool for overcoming the major limitations of US-guided pRFA.
Full Text
https://www.sciencedirect.com/science/article/pii/S0720048X11006784
DOI
10.1016/j.ejrad.2011.08.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178464
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