Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians

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Authors: Joo-Yeon Hwang ; Xueling Sim ; Ying Wu ; Jun Liang ; Yasuharu Tabara ; Cheng Hu ; Kazuo Hara ; Claudia H T Tam ; Qiuyin Cai ; Qi Zhao ; Sunha Jee ; Fumihiko Takeuchi ; Min Jin Go ; Rick Twee Hee Ong ; Takayoshi Ohkubo ; Young Jin Kim ; Rong Zhang ; Toshimasa Yamauchi ; Wing Yee So ; Jirong Long ; Dongfeng Gu ; Nanette R Lee ; Soriul Kim ; Tomohiro Katsuya ; Ji Hee Oh ; Jianjun Liu ; Satoshi Umemura ; Yeon-Jung Kim ; Feng Jiang ; Shiro Maeda ; Juliana C N Chan ; Wei Lu ; James E Hixson ; Linda S Adair ; Keum Ji Jung ; Toru Nabika ; Jae-Bum Bae ; Mi Hee Lee ; Mark Seielstad ; Terri L Young ; Yik Ying Teo ; Yoshikuni Kita ; Naoyuki Takashima ; Haruhiko Osawa ; So-Hyun Lee ; Min-Ho Shin ; Dong Hoon Shin ; Bo Youl Choi ; Jiajun Shi ; Yu-Tang Gao ; Yong-Bing Xiang ; Wei Zheng ; Norihiro Kato ; Miwuk Yoon ; Jiang He ; Xiao Ou Shu ; Ronald C W Ma ; Takashi Kadowaki ; Weiping Jia ; Tetsuro Miki ; Lu Qi ; E Shyong Tai ; Karen L Mohlke ; Bok-Ghee Han ; Yoon Shin Cho ; Bong-Jo Kim

MeSH: Adult ; Aged ; Asian Continental Ancestry Group / genetics* ; Blood Glucose / genetics* ; Blood Glucose / metabolism* ; Far East ; Fasting ; Female ; Genetic Variation ; Genome-Wide Association Study* ; Genotype ; Guanine Nucleotide Exchange Factors / genetics ; Humans ; Male ; Middle Aged ; Phenotype ; Protein-Serine-Threonine Kinases / genetics ; Pyruvate Dehydrogenase (Acetyl-Transferring) Kinase ; Receptor, IGF Type 1 / genetics ; Tumor Suppressor Proteins / genetics

Abstract: Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.