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Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians

Authors
 Joo-Yeon Hwang  ;  Xueling Sim  ;  Ying Wu  ;  Jun Liang  ;  Yasuharu Tabara  ;  Cheng Hu  ;  Kazuo Hara  ;  Claudia H T Tam  ;  Qiuyin Cai  ;  Qi Zhao  ;  Sunha Jee  ;  Fumihiko Takeuchi  ;  Min Jin Go  ;  Rick Twee Hee Ong  ;  Takayoshi Ohkubo  ;  Young Jin Kim  ;  Rong Zhang  ;  Toshimasa Yamauchi  ;  Wing Yee So  ;  Jirong Long  ;  Dongfeng Gu  ;  Nanette R Lee  ;  Soriul Kim  ;  Tomohiro Katsuya  ;  Ji Hee Oh  ;  Jianjun Liu  ;  Satoshi Umemura  ;  Yeon-Jung Kim  ;  Feng Jiang  ;  Shiro Maeda  ;  Juliana C N Chan  ;  Wei Lu  ;  James E Hixson  ;  Linda S Adair  ;  Keum Ji Jung  ;  Toru Nabika  ;  Jae-Bum Bae  ;  Mi Hee Lee  ;  Mark Seielstad  ;  Terri L Young  ;  Yik Ying Teo  ;  Yoshikuni Kita  ;  Naoyuki Takashima  ;  Haruhiko Osawa  ;  So-Hyun Lee  ;  Min-Ho Shin  ;  Dong Hoon Shin  ;  Bo Youl Choi  ;  Jiajun Shi  ;  Yu-Tang Gao  ;  Yong-Bing Xiang  ;  Wei Zheng  ;  Norihiro Kato  ;  Miwuk Yoon  ;  Jiang He  ;  Xiao Ou Shu  ;  Ronald C W Ma  ;  Takashi Kadowaki  ;  Weiping Jia  ;  Tetsuro Miki  ;  Lu Qi  ;  E Shyong Tai  ;  Karen L Mohlke  ;  Bok-Ghee Han  ;  Yoon Shin Cho  ;  Bong-Jo Kim 
Citation
 DIABETES, Vol.64(1) : 291-298, 2015-01 
Journal Title
 DIABETES 
ISSN
 0012-1797 
Issue Date
2015-01
MeSH
Adult ; Aged ; Asian Continental Ancestry Group / genetics* ; Blood Glucose / genetics* ; Blood Glucose / metabolism* ; Far East ; Fasting ; Female ; Genetic Variation ; Genome-Wide Association Study* ; Genotype ; Guanine Nucleotide Exchange Factors / genetics ; Humans ; Male ; Middle Aged ; Phenotype ; Protein-Serine-Threonine Kinases / genetics ; Pyruvate Dehydrogenase (Acetyl-Transferring) Kinase ; Receptor, IGF Type 1 / genetics ; Tumor Suppressor Proteins / genetics
Abstract
Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
Files in This Item:
T201506880.pdf Download
DOI
10.2337/db14-0563
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178457
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