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A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation

Authors
 Chang-Su Kim  ;  Jin-Hee Kim  ;  Bokyoung Kim  ;  Young-Seok Park  ;  Hong-Kyun Kim  ;  Hieu Trung Tran  ;  Sang Hoon Kim  ;  Hojeong Jeon  ;  Sangjib Kim  ;  Ji Hyun Sim  ;  Hyun Mu Shin  ;  Gwanghun Kim  ;  Young Joo Baik  ;  Kee-Joon Lee  ;  Hae-Young Kim  ;  Tae Jin Yun  ;  Youn Sang Kim  ;  Hang-Rae Kim 
Citation
 ADVANCED FUNCTIONAL MATERIALS, Vol.27(44) : 1703569, 2017-11 
Journal Title
 ADVANCED FUNCTIONAL MATERIALS 
ISSN
 1616-301X 
Issue Date
2017-11
Keywords
bone regeneration ; groove pattern ; inflammation ; osteoblast ; reactive oxygen species
Abstract
Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges (0.35−7 µm) and grooves (0.65−6 µm) of various widths and explored their mechanisms in improving osteoblast differentiation. This study finds that a groove pattern enhancing osteoblast differentiation is associated with the ability of the cell to extend its length and that it is able to overcome the inhibition of osteoblast differentiation that takes place under inflammatory conditions. The groove pattern suppresses the generation of reactive oxygen species, a reaction that is increased in inflammatory conditions. It also modulates the expression of osteogenic factors according to differentiation time. Importantly, specific groove patterns AZ‐2 and AZ‐4, with ridge width of 2 µm and groove width of 2 or 4 µm, respectively, effectively promote bone regeneration in critical‐sized calvarial defects without additional factors. This knowledge of groove patterns can be applied to the development of orthopedic and dental devices.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201703569
DOI
10.1002/adfm.201703569
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kee Joon(이기준) ORCID logo https://orcid.org/0000-0002-0782-3128
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178299
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