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A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation

DC FieldValueLanguage
dc.contributor.author이기준-
dc.date.accessioned2020-07-16T16:46:11Z-
dc.date.available2020-07-16T16:46:11Z-
dc.date.issued2017-11-
dc.identifier.issn1616-301X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178299-
dc.description.abstractLittle is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges (0.35−7 µm) and grooves (0.65−6 µm) of various widths and explored their mechanisms in improving osteoblast differentiation. This study finds that a groove pattern enhancing osteoblast differentiation is associated with the ability of the cell to extend its length and that it is able to overcome the inhibition of osteoblast differentiation that takes place under inflammatory conditions. The groove pattern suppresses the generation of reactive oxygen species, a reaction that is increased in inflammatory conditions. It also modulates the expression of osteogenic factors according to differentiation time. Importantly, specific groove patterns AZ‐2 and AZ‐4, with ridge width of 2 µm and groove width of 2 or 4 µm, respectively, effectively promote bone regeneration in critical‐sized calvarial defects without additional factors. This knowledge of groove patterns can be applied to the development of orthopedic and dental devices.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-VCH-
dc.relation.isPartOfADVANCED FUNCTIONAL MATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleA Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Orthodontics (교정과학교실)-
dc.contributor.googleauthorChang-Su Kim-
dc.contributor.googleauthorJin-Hee Kim-
dc.contributor.googleauthorBokyoung Kim-
dc.contributor.googleauthorYoung-Seok Park-
dc.contributor.googleauthorHong-Kyun Kim-
dc.contributor.googleauthorHieu Trung Tran-
dc.contributor.googleauthorSang Hoon Kim-
dc.contributor.googleauthorHojeong Jeon-
dc.contributor.googleauthorSangjib Kim-
dc.contributor.googleauthorJi Hyun Sim-
dc.contributor.googleauthorHyun Mu Shin-
dc.contributor.googleauthorGwanghun Kim-
dc.contributor.googleauthorYoung Joo Baik-
dc.contributor.googleauthorKee-Joon Lee-
dc.contributor.googleauthorHae-Young Kim-
dc.contributor.googleauthorTae Jin Yun-
dc.contributor.googleauthorYoun Sang Kim-
dc.contributor.googleauthorHang-Rae Kim-
dc.identifier.doi10.1002/adfm.201703569-
dc.contributor.localIdA02698-
dc.relation.journalcodeJ00041-
dc.identifier.eissn1616-3028-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201703569-
dc.subject.keywordbone regeneration-
dc.subject.keywordgroove pattern-
dc.subject.keywordinflammation-
dc.subject.keywordosteoblast-
dc.subject.keywordreactive oxygen species-
dc.contributor.alternativeNameLee, Kee Joon-
dc.contributor.affiliatedAuthor이기준-
dc.citation.volume27-
dc.citation.number44-
dc.citation.startPage1703569-
dc.identifier.bibliographicCitationADVANCED FUNCTIONAL MATERIALS, Vol.27(44) : 1703569, 2017-11-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers

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