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The Dissected Aorta part I. Early anatomic changes in an in vitro model

 David M. Williams  ;  Mark A. LePage  ;  Do Yun Lee 
 RADIOLOGY, Vol.203(1) : 23-31, 1997 
Journal Title
Issue Date
Acute Disease ; Aneurysm, Dissecting/diagnostic imaging* ; Aneurysm, Dissecting/physiopathology ; Animals ; Aorta/diagnostic imaging ; Aortic Aneurysm/diagnostic imaging* ; Aortic Aneurysm/physiopathology ; Humans ; Hydrostatic Pressure ; In Vitro Techniques ; Swine ; Ultrasonography, Interventional
PURPOSE: To define early anatomic changes in the aorta in an in vitro hydrostatic model of acute aortic dissection. MATERIALS AND METHODS: Aortic dissections were created in explanted aortas. A small portion of the dissection flap was resected to allow free communication between the true and false lumina. The aortas were suspended in a saline bath and distended by means of a saline fluid column. By using intravascular ultrasonography, the arc lengths of the outer walls of the true and false lumina and of the dissection flap were measured at increasing hydrostatic pressures and at increasing fractions of dissected wall circumference. RESULTS: The dissected aorta immediately became ectatic. At a given fraction of wall circumference involved in dissection, total aortic cross-sectional area increased with increased hydrostatic pressure. At a given hydrostatic pressure, this area increased with increased fraction of wall circumference dissected. Most of the increase was due to dilatation of the false lumen. There were minimal changes in true-lumen size. Dissection flap length, after initial contraction at the time of dissection, changed minimally with increasing pressure. CONCLUSION: Anatomic changes in the dissected aorta depend on hydrostatic pressure and on the percentage of aortic wall involved in the dissection.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Do Yun(이도연)
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