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Effects of Repeated Short versus Single Long Episodes of Focal Ischemia on Somatosensory Evoked Potentials and Development of Cerebral Infarction in Cats

Authors
 Kyu Chang LEE  ;  Jin Yang JOO  ;  Seung Kon HUH  ;  Tai Seung KIM 
Citation
 NEUROLOGIA MEDICO-CHIRURGICA, Vol.37(6) : 447-452, 1997 
Journal Title
 NEUROLOGIA MEDICO-CHIRURGICA 
ISSN
 0470-8105 
Issue Date
1997
MeSH
Animals ; Brain Ischemia/pathology ; Brain Ischemia/physiopathology* ; Cats ; Cerebral Infarction/pathology ; Cerebral Infarction/physiopathology* ; Disease Models, Animal ; Evoked Potentials, Somatosensory/physiology* ; Time Factors
Abstract
The effects of repeated short episodes of focal ischemia at 30-minute intervals or a single equivalent long episode of focal ischemia on neuronal function and development of cerebral infarction were compared using somatosensory evoked potential (SEP) recording and 2,3,5-triphenyltetrazolium chloride staining in a cat model. Seventeen cats underwent transorbital occlusion of the middle cerebral artery (MCA), using one of three procedures: sham-operation; single 1-hour occlusion of the MCA, followed by 3 hours of recirculation; or three 20-minute occlusions of the MCA at 30-minute intervals, followed by 3 hours of recirculation. Two of six cats in the single long-term occlusion group showed recovery of SEP, whereas all six cats in the repeated short-term occlusion group showed recovery of SEP at 3 hours after recirculation. All six cats in the single long-term occlusion group had cerebral infarction of various sizes, but only one cat in the repeated short-term occlusion group developed infarction. Repeated short episodes of focal ischemia are relatively less damaging than a single equivalent long episode of focal ischemia, even if the reperfusion interval is extended to 30 minutes.
Files in This Item:
T199702913.pdf Download
DOI
10.2176/nmc.37.447
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Joo, Jin Yang(주진양)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177384
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