분리 위선세포에서 가역성 프로톤 펌프 억제제 YH1238 및 YH1885의 위산분비 억제효과

Abstract

Antiulcer effects of YH1238 and YH1885 were determined in the isolated gastric cells from human and rabbit stomach. Intracellular accumulation of [14C]-aminopyrine and [14C]-glucose oxidation were used as indicators of acid secretory ability of the gastric cells. Unstimulated and stimulated gastric cells with dibutyryl cAMP(10-3M) were used and the inhibitory effects of YH1238 and YH1885 on acid secretion were compared with known proton pump inhibitors such as omeprazole and SK&F 96067. Dibutyryl cAMP stimulated the [14C]-aminopyrine accumulation and [14C]-glucose oxidation, which were inhibited by YH1238, YH1885, SK&F 96067 and omeprazole. Inhibitory effects of YH1238, YH1885 and omeprazole on [14C]-aminopyrine accumulation in stimulated gastric cells were more potent than that of SK&F 96067 at the concentration of 10-5M. It is suggested that the reversible proton pump inhibitors YH1238 and YH1885 would be effective antiulcer agents.