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분리 위선세포에서 가역성 프로톤 펌프 억제제 YH1238 및 YH1885의 위산분비 억제효과

Other Titles
 Inhibitory Effects of Reversible Proton Pump Inhibitors YH 1238 and YH1885 on Acid Secretion in Isolated Gastric Cells 
Authors
 김혜영  ;  김동구  ;  이봉용  ;  이종욱  ;  김경환 
Citation
 KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.1(3) : 337-343, 1997 
Journal Title
 KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 
ISSN
 1226-4512 
Issue Date
1997
Abstract
Antiulcer effects of YH1238 and YH1885 were determined in the isolated gastric cells from human and rabbit stomach. Intracellular accumulation of [14C]-aminopyrine and [14C]-glucose oxidation were used as indicators of acid secretory ability of the gastric cells. Unstimulated and stimulated gastric cells with dibutyryl cAMP(10-3M) were used and the inhibitory effects of YH1238 and YH1885 on acid secretion were compared with known proton pump inhibitors such as omeprazole and SK&F 96067. Dibutyryl cAMP stimulated the [14C]-aminopyrine accumulation and [14C]-glucose oxidation, which were inhibited by YH1238, YH1885, SK&F 96067 and omeprazole. Inhibitory effects of YH1238, YH1885 and omeprazole on [14C]-aminopyrine accumulation in stimulated gastric cells were more potent than that of SK&F 96067 at the concentration of 10-5M. It is suggested that the reversible proton pump inhibitors YH1238 and YH1885 would be effective antiulcer agents.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
Kim, Dong Goo(김동구)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177370
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