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분리 위선세포에서 가역성 프로톤 펌프 억제제 YH1238 및 YH1885의 위산분비 억제효과
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 김동구 | - |
dc.date.accessioned | 2020-07-03T17:14:15Z | - |
dc.date.available | 2020-07-03T17:14:15Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177370 | - |
dc.description.abstract | Antiulcer effects of YH1238 and YH1885 were determined in the isolated gastric cells from human and rabbit stomach. Intracellular accumulation of [14C]-aminopyrine and [14C]-glucose oxidation were used as indicators of acid secretory ability of the gastric cells. Unstimulated and stimulated gastric cells with dibutyryl cAMP(10-3M) were used and the inhibitory effects of YH1238 and YH1885 on acid secretion were compared with known proton pump inhibitors such as omeprazole and SK&F 96067. Dibutyryl cAMP stimulated the [14C]-aminopyrine accumulation and [14C]-glucose oxidation, which were inhibited by YH1238, YH1885, SK&F 96067 and omeprazole. Inhibitory effects of YH1238, YH1885 and omeprazole on [14C]-aminopyrine accumulation in stimulated gastric cells were more potent than that of SK&F 96067 at the concentration of 10-5M. It is suggested that the reversible proton pump inhibitors YH1238 and YH1885 would be effective antiulcer agents. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한약리학회 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 분리 위선세포에서 가역성 프로톤 펌프 억제제 YH1238 및 YH1885의 위산분비 억제효과 | - |
dc.title.alternative | Inhibitory Effects of Reversible Proton Pump Inhibitors YH 1238 and YH1885 on Acid Secretion in Isolated Gastric Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | 김혜영 | - |
dc.contributor.googleauthor | 김동구 | - |
dc.contributor.googleauthor | 이봉용 | - |
dc.contributor.googleauthor | 이종욱 | - |
dc.contributor.googleauthor | 김경환 | - |
dc.contributor.localId | A00311 | - |
dc.contributor.localId | A00396 | - |
dc.relation.journalcode | J02104 | - |
dc.identifier.eissn | 2093-3827 | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.contributor.affiliatedAuthor | 김동구 | - |
dc.citation.volume | 1 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 337 | - |
dc.citation.endPage | 343 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.1(3) : 337-343, 1997 | - |
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