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Hypothermia and Minimal Fluid Resuscitation Increase Survival after Uncontrolled Hemorrhagic Shock in Rats

Authors
 Kim, Seung-Ho  ;  Stezoski, S. William  ;  Safar, Peter  ;  Capone, Antonio  ;  Tisherman, Samuel 
Citation
 Journal of Trauma, Vol.42(2) : 213-222, 1997 
Journal Title
 Journal of Trauma 
ISSN
 0022-5282 
Issue Date
1997
MeSH
Animals ; Blood Pressure ; Disease Models, Animal ; Hypothermia, Induced* ; Male ; Rats ; Rats, Sprague-Dawley ; Resuscitation* ; Shock, Hemorrhagic/mortality ; Shock, Hemorrhagic/therapy* ; Survival Rate
Abstract
To test the hypothesis that protective-preservative moderate hypothermia during uncontrolled hemorrhagic shock (UHS) in rats increases survival. DESIGN: Randomized outcome study in rats. MATERIALS AND METHODS: UHS phase I of 90 minutes, with initial withdrawal of 3 mL/100 g of blood plus tail amputation, was followed by hemostasis and all-out resuscitation phase II from 90 to 150 minutes, and observation phase III to 72 hours. Forty male rats under light anesthesia and spontaneous breathing were randomized into four groups: Group 1 received no fluid resuscitation during UHS and normothermia (37.5 degrees C) throughout. Group 2 received no fluid resuscitation and hypothermia (30 degrees C) from 15 to 120 minutes. Group 3 received lactated Ringer's solution to maintain mean arterial pressure at 40 mm Hg during UHS and normothermia. Group 4 received lactated Ringer's solution to a mean arterial pressure of 40 mm Hg during UHS and hypothermia from 15 to 120 minutes. RESULTS: UHS phase I was survived by 0 of 10 rats in group 1, 7 of 10 in group 2, 5 of 10 in group 3, and 10 of 10 in group 4 (p < 0.01 for group 1 vs. 2, 3, or 4; p < 0.05 for group 4 vs. 3). Survival to 72 hours was achieved by 0 of 10 rats in group 1, 3 of 10 in group 2 (p < 0.001 vs. group 1), 1 of 10 in group 3, and 7 of 10 in group 4 (p < 0.001 vs. group 1, and p < 0.01 vs. group 3). All 72-hour survivors were neurologically normal. Necropsies in rats that died early during phase III showed edema and gastrointestinal hemorrhages. CONCLUSIONS: Moderate hypothermia or limited (hypotensive) fluid resuscitation --best both combined--increases survival during and after UHS in rats.
Full Text
https://journals.lww.com/jtrauma/Fulltext/1997/02000/Hypothermia_and_Minimal_Fluid_Resuscitation.6.aspx
DOI
10.1097/00005373-199702000-00006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Ho(김승호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177350
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