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Hypothermia and Minimal Fluid Resuscitation Increase Survival after Uncontrolled Hemorrhagic Shock in Rats

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dc.contributor.author김승호-
dc.date.accessioned2020-07-03T17:12:42Z-
dc.date.available2020-07-03T17:12:42Z-
dc.date.issued1997-
dc.identifier.issn0022-5282-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177350-
dc.description.abstractTo test the hypothesis that protective-preservative moderate hypothermia during uncontrolled hemorrhagic shock (UHS) in rats increases survival. DESIGN: Randomized outcome study in rats. MATERIALS AND METHODS: UHS phase I of 90 minutes, with initial withdrawal of 3 mL/100 g of blood plus tail amputation, was followed by hemostasis and all-out resuscitation phase II from 90 to 150 minutes, and observation phase III to 72 hours. Forty male rats under light anesthesia and spontaneous breathing were randomized into four groups: Group 1 received no fluid resuscitation during UHS and normothermia (37.5 degrees C) throughout. Group 2 received no fluid resuscitation and hypothermia (30 degrees C) from 15 to 120 minutes. Group 3 received lactated Ringer's solution to maintain mean arterial pressure at 40 mm Hg during UHS and normothermia. Group 4 received lactated Ringer's solution to a mean arterial pressure of 40 mm Hg during UHS and hypothermia from 15 to 120 minutes. RESULTS: UHS phase I was survived by 0 of 10 rats in group 1, 7 of 10 in group 2, 5 of 10 in group 3, and 10 of 10 in group 4 (p < 0.01 for group 1 vs. 2, 3, or 4; p < 0.05 for group 4 vs. 3). Survival to 72 hours was achieved by 0 of 10 rats in group 1, 3 of 10 in group 2 (p < 0.001 vs. group 1), 1 of 10 in group 3, and 7 of 10 in group 4 (p < 0.001 vs. group 1, and p < 0.01 vs. group 3). All 72-hour survivors were neurologically normal. Necropsies in rats that died early during phase III showed edema and gastrointestinal hemorrhages. CONCLUSIONS: Moderate hypothermia or limited (hypotensive) fluid resuscitation --best both combined--increases survival during and after UHS in rats.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfJournal of Trauma-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHBlood Pressure-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHHypothermia, Induced*-
dc.subject.MESHMale-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHResuscitation*-
dc.subject.MESHShock, Hemorrhagic/mortality-
dc.subject.MESHShock, Hemorrhagic/therapy*-
dc.subject.MESHSurvival Rate-
dc.titleHypothermia and Minimal Fluid Resuscitation Increase Survival after Uncontrolled Hemorrhagic Shock in Rats-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Emergency Medicine (응급의학교실)-
dc.contributor.googleauthorKim, Seung-Ho-
dc.contributor.googleauthorStezoski, S. William-
dc.contributor.googleauthorSafar, Peter-
dc.contributor.googleauthorCapone, Antonio-
dc.contributor.googleauthorTisherman, Samuel-
dc.identifier.doi10.1097/00005373-199702000-00006-
dc.contributor.localIdA00667-
dc.relation.journalcodeJ01916-
dc.identifier.eissn1529-8809-
dc.identifier.pmid9042871-
dc.identifier.urlhttps://journals.lww.com/jtrauma/Fulltext/1997/02000/Hypothermia_and_Minimal_Fluid_Resuscitation.6.aspx-
dc.contributor.alternativeNameKim, Seung Ho-
dc.contributor.affiliatedAuthor김승호-
dc.citation.volume42-
dc.citation.number2-
dc.citation.startPage213-
dc.citation.endPage222-
dc.identifier.bibliographicCitationJournal of Trauma, Vol.42(2) : 213-222, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers

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