Cited 98 times in
Hypothermia and Minimal Fluid Resuscitation Increase Survival after Uncontrolled Hemorrhagic Shock in Rats
DC Field | Value | Language |
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dc.contributor.author | 김승호 | - |
dc.date.accessioned | 2020-07-03T17:12:42Z | - |
dc.date.available | 2020-07-03T17:12:42Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0022-5282 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177350 | - |
dc.description.abstract | To test the hypothesis that protective-preservative moderate hypothermia during uncontrolled hemorrhagic shock (UHS) in rats increases survival. DESIGN: Randomized outcome study in rats. MATERIALS AND METHODS: UHS phase I of 90 minutes, with initial withdrawal of 3 mL/100 g of blood plus tail amputation, was followed by hemostasis and all-out resuscitation phase II from 90 to 150 minutes, and observation phase III to 72 hours. Forty male rats under light anesthesia and spontaneous breathing were randomized into four groups: Group 1 received no fluid resuscitation during UHS and normothermia (37.5 degrees C) throughout. Group 2 received no fluid resuscitation and hypothermia (30 degrees C) from 15 to 120 minutes. Group 3 received lactated Ringer's solution to maintain mean arterial pressure at 40 mm Hg during UHS and normothermia. Group 4 received lactated Ringer's solution to a mean arterial pressure of 40 mm Hg during UHS and hypothermia from 15 to 120 minutes. RESULTS: UHS phase I was survived by 0 of 10 rats in group 1, 7 of 10 in group 2, 5 of 10 in group 3, and 10 of 10 in group 4 (p < 0.01 for group 1 vs. 2, 3, or 4; p < 0.05 for group 4 vs. 3). Survival to 72 hours was achieved by 0 of 10 rats in group 1, 3 of 10 in group 2 (p < 0.001 vs. group 1), 1 of 10 in group 3, and 7 of 10 in group 4 (p < 0.001 vs. group 1, and p < 0.01 vs. group 3). All 72-hour survivors were neurologically normal. Necropsies in rats that died early during phase III showed edema and gastrointestinal hemorrhages. CONCLUSIONS: Moderate hypothermia or limited (hypotensive) fluid resuscitation --best both combined--increases survival during and after UHS in rats. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | Journal of Trauma | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Hypothermia, Induced* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Resuscitation* | - |
dc.subject.MESH | Shock, Hemorrhagic/mortality | - |
dc.subject.MESH | Shock, Hemorrhagic/therapy* | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Hypothermia and Minimal Fluid Resuscitation Increase Survival after Uncontrolled Hemorrhagic Shock in Rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Emergency Medicine (응급의학교실) | - |
dc.contributor.googleauthor | Kim, Seung-Ho | - |
dc.contributor.googleauthor | Stezoski, S. William | - |
dc.contributor.googleauthor | Safar, Peter | - |
dc.contributor.googleauthor | Capone, Antonio | - |
dc.contributor.googleauthor | Tisherman, Samuel | - |
dc.identifier.doi | 10.1097/00005373-199702000-00006 | - |
dc.contributor.localId | A00667 | - |
dc.relation.journalcode | J01916 | - |
dc.identifier.eissn | 1529-8809 | - |
dc.identifier.pmid | 9042871 | - |
dc.identifier.url | https://journals.lww.com/jtrauma/Fulltext/1997/02000/Hypothermia_and_Minimal_Fluid_Resuscitation.6.aspx | - |
dc.contributor.alternativeName | Kim, Seung Ho | - |
dc.contributor.affiliatedAuthor | 김승호 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 213 | - |
dc.citation.endPage | 222 | - |
dc.identifier.bibliographicCitation | Journal of Trauma, Vol.42(2) : 213-222, 1997 | - |
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