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Radionuclide Therapy of Skin Cancers and Bowen's Disease Using a Specially Designed Skin Patch
DC Field | Value | Language |
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dc.contributor.author | 박광균 | - |
dc.contributor.author | 유형식 | - |
dc.contributor.author | 이민걸 | - |
dc.contributor.author | 이종두 | - |
dc.contributor.author | 이종태 | - |
dc.date.accessioned | 2020-07-03T17:11:53Z | - |
dc.date.available | 2020-07-03T17:11:53Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177341 | - |
dc.description.abstract | Skin cancer is the most common malignancy in humans. Therapeutic modalities for skin cancer are local destruction, radiotherapy and surgery. External radiation therapy leads to good results, however, generally 5-6 wk of treatment is needed to deliver optimal radiation dose to tumors. In this study, a beta-emitting radionuclide, 166Ho, impregnated in a specially designed patch, was used on superficial skin cancers and Bowen's disease for local irradiation. METHODS: Ten mice with chemically induced skin tumors were studied. Five-millimeter size patches containing 22.2-72.15 MBq (0.6-1.95 mCi) 166Ho were applied to the tumor surface for 1-2 hr. In a human trial, patients with squamous-cell carcinoma (n = 3), basal cell carcinoma (n = 1) and Bowen's disease (n = 1) were treated with patches containing 273.8-999 MBq (7.4-27 mCi) of 166Ho for 30 min to 1 hr. Pathologic examination was performed 4-7 wk after treatment in an animal model. Skin biopsy was performed 8 wk post-treatment in four patients. RESULTS: Tumor destruction was seen 1 wk post-treatment, however, radiation dermatitis or ulceration developed at the site of radionuclide application. Those reactions healed gradually with fibrosis or epithelialization, which was confirmed pathologically. No significant adverse reaction to radiation except subcutaneous fibrosis was found. CONCLUSION: Superficial skin tumors could be successfully treated by topical application of beta-emitting radionuclides. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Society of Nuclear Medicine | - |
dc.relation.isPartOf | JOURNAL OF NUCLEAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bowen's Disease/radiotherapy* | - |
dc.subject.MESH | Brachytherapy/methods* | - |
dc.subject.MESH | Carcinoma, Basal Cell/radiotherapy* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/radiotherapy* | - |
dc.subject.MESH | Computer Simulation | - |
dc.subject.MESH | Dose-Response Relationship, Radiation | - |
dc.subject.MESH | Feasibility Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Holmium/administration & dosage* | - |
dc.subject.MESH | Holmium/therapeutic use | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Hairless | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Radiodermatitis/etiology | - |
dc.subject.MESH | Radioisotopes/administration & dosage* | - |
dc.subject.MESH | Radioisotopes/therapeutic use | - |
dc.subject.MESH | Skin Neoplasms/radiotherapy* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Radionuclide Therapy of Skin Cancers and Bowen's Disease Using a Specially Designed Skin Patch | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Kwang Kyun Park | - |
dc.contributor.googleauthor | Min-Geol Lee | - |
dc.contributor.googleauthor | Eun-Hee Kim | - |
dc.contributor.googleauthor | Kyung un Rhim | - |
dc.contributor.googleauthor | Jong Tae Lee | - |
dc.contributor.googleauthor | Hyung Sik Yoo | - |
dc.contributor.googleauthor | Young Mi Kim | - |
dc.contributor.googleauthor | Kyung Bae Park | - |
dc.contributor.googleauthor | Jae Rok Kim | - |
dc.contributor.localId | A01429 | - |
dc.contributor.localId | A02533 | - |
dc.contributor.localId | A02779 | - |
dc.contributor.localId | A03138 | - |
dc.contributor.localId | A03150 | - |
dc.relation.journalcode | J01644 | - |
dc.identifier.eissn | 1535-5667 | - |
dc.identifier.pmid | 9170430 | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | 박광균 | - |
dc.contributor.affiliatedAuthor | 유형식 | - |
dc.contributor.affiliatedAuthor | 이민걸 | - |
dc.contributor.affiliatedAuthor | 이종두 | - |
dc.contributor.affiliatedAuthor | 이종태 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 697 | - |
dc.citation.endPage | 702 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUCLEAR MEDICINE, Vol.38(5) : 697-702, 1997 | - |
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