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Clonal expansion of CD8+ T cells in Kawasaki disease

 In-Hong Choi  ;  Yong-Jun Chwae  ;  Woo-Sup Shim  ;  Dong-Soo Kim  ;  Dae-Ho Kwon  ;  Joo-Deuk Kim  ;  Se-long Kim 
 JOURNAL OF IMMUNOLOGY, Vol.159(1) : 481-486, 1997 
Journal Title
Issue Date
Amino Acid Sequence ; Antigens, CD/genetics ; Antigens, CD/immunology* ; CD8-Positive T-Lymphocytes/immunology* ; Cell Lineage ; Child, Preschool ; Clone Cells ; Humans ; Lymphocyte Activation ; Molecular Sequence Data ; Mucocutaneous Lymph Node Syndrome/immunology* ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology* ; Superantigens/immunology*
Kawasaki disease (KD) is the major cause of acquired heart disease in children. KD is suspected of being an infectious disease, but the etiology has not yet been clarified. Immunologically, the disease is associated with the activation of T cells, monocytes, and macrophages resulting in highly elevated levels of several cytokines. Recently, expansions of T cells expressing TCRBV2 and TCRBV8 chains have been reported, and this suggests the involvement of a superantigen in the pathogenesis of KD. To address the role of a superantigen in KD, we investigated clonal expansion of T cells by estimating the complementarity-determining region 3 size profile among T cells expressing TCRBV1, TCRBV2, TCRBV4, TCRBV5, TCRBV8, TCRBV14, TCRBV16, TCRBV17, TCRBV18, and TCRBV20 chains during acute KD, during subacute KD, and during the long term follow-up period. During the acute phase of KD, several clonal expansions were found mainly in the CD8+ T cells that disappeared during the long term follow-up period. Our data suggest that the conventional Ags rather than a superantigen were involved in the pathogenesis of acute KD.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Kim, Se Jong(김세종)
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
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