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Deletion of the M6P/IGF2r gene in primary hepatocellular carcinoma

Authors
 Zhe Piao  ;  Youjeong Choi  ;  Chanil Park  ;  Woo Jung Lee  ;  Jeon-Han Park  ;  Hoguen Kim 
Citation
 CANCER LETTERS, Vol.120(1) : 39-43, 1997 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
1997
MeSH
Carcinoma, Hepatocellular/genetics* ; Carcinoma, Hepatocellular/pathology ; Chromosomes, Human, Pair 6 ; DNA, Neoplasm/genetics* ; DNA-Binding Proteins* ; Dinucleotide Repeats ; Gene Deletion ; Humans ; Liver Neoplasms/genetics* ; Liver Neoplasms/pathology ; Loss of Heterozygosity ; Receptor, IGF Type 2/genetics* ; Smad4 Protein ; Trans-Activators/genetics
Abstract
To evaluate the different alteration patterns of the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2r) gene in hepatocellular carcinoma (HCC), 41 HCCs were screened for homozygous deletion and loss of heterozygosity (LOH) at the M6P/IGF2r gene with a dinucleotide repeat polymorphic marker. Of these, three (8.8%) were heterozygous and LOH was observed in two (66.7%) of these informative cases. Five (14.7%) out of 34 informative cases showed homozygous deletions for the dinucleotide repeat polymorphic marker. The frequent allelic loss and homozygous deletion of the M6P/ IGF2r gene suggest that the M6P/IGF2r gene functions as a tumor suppressor gene in the development of HCC.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304383597002899?via%3Dihub
DOI
10.1016/s0304-3835(97)00289-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
Park, Chan Il(박찬일)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177278
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