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Deletion of the M6P/IGF2r gene in primary hepatocellular carcinoma

DC FieldValueLanguage
dc.contributor.author김호근-
dc.contributor.author박전한-
dc.contributor.author박찬일-
dc.contributor.author박전한-
dc.contributor.author박찬일-
dc.date.accessioned2020-07-03T17:06:53Z-
dc.date.available2020-07-03T17:06:53Z-
dc.date.issued1997-
dc.identifier.issn0304-3835-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177278-
dc.description.abstractTo evaluate the different alteration patterns of the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2r) gene in hepatocellular carcinoma (HCC), 41 HCCs were screened for homozygous deletion and loss of heterozygosity (LOH) at the M6P/IGF2r gene with a dinucleotide repeat polymorphic marker. Of these, three (8.8%) were heterozygous and LOH was observed in two (66.7%) of these informative cases. Five (14.7%) out of 34 informative cases showed homozygous deletions for the dinucleotide repeat polymorphic marker. The frequent allelic loss and homozygous deletion of the M6P/ IGF2r gene suggest that the M6P/IGF2r gene functions as a tumor suppressor gene in the development of HCC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Ireland-
dc.relation.isPartOfCANCER LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCarcinoma, Hepatocellular/genetics*-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHChromosomes, Human, Pair 6-
dc.subject.MESHDNA, Neoplasm/genetics*-
dc.subject.MESHDNA-Binding Proteins*-
dc.subject.MESHDinucleotide Repeats-
dc.subject.MESHGene Deletion-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/genetics*-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHLoss of Heterozygosity-
dc.subject.MESHReceptor, IGF Type 2/genetics*-
dc.subject.MESHSmad4 Protein-
dc.subject.MESHTrans-Activators/genetics-
dc.titleDeletion of the M6P/IGF2r gene in primary hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorZhe Piao-
dc.contributor.googleauthorYoujeong Choi-
dc.contributor.googleauthorChanil Park-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorJeon-Han Park-
dc.contributor.googleauthorHoguen Kim-
dc.identifier.doi10.1016/s0304-3835(97)00289-9-
dc.contributor.localIdA01183-
dc.contributor.localIdA01641-
dc.contributor.localIdA01641-
dc.contributor.localIdA01710-
dc.contributor.localIdA01710-
dc.contributor.localIdA01641-
dc.contributor.localIdA01641-
dc.contributor.localIdA01710-
dc.contributor.localIdA01710-
dc.relation.journalcodeJ00448-
dc.identifier.eissn1872-7980-
dc.identifier.pmid9570384-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0304383597002899?via%3Dihub-
dc.contributor.alternativeNameKim, Hogeun-
dc.contributor.affiliatedAuthor김호근-
dc.contributor.affiliatedAuthor박전한-
dc.contributor.affiliatedAuthor박전한-
dc.contributor.affiliatedAuthor박찬일-
dc.contributor.affiliatedAuthor박찬일-
dc.contributor.affiliatedAuthor박전한-
dc.contributor.affiliatedAuthor박전한-
dc.contributor.affiliatedAuthor박찬일-
dc.contributor.affiliatedAuthor박찬일-
dc.citation.volume120-
dc.citation.number1-
dc.citation.startPage39-
dc.citation.endPage43-
dc.identifier.bibliographicCitationCANCER LETTERS, Vol.120(1) : 39-43, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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