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Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat

Authors
 Soon Hyun Kim  ;  Young Kwang Chu  ;  Oh Woong Kwon  ;  Sylvia A McCune  ;  Frederick H Davidorf 
Citation
 YONSEI MEDICAL JOURNAL, Vol.39(5) : 453-462, 1998 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
1998
MeSH
Animals ; Diabetic Retinopathy/pathology* ; Disease Models, Animal ; Female ; Hybridization, Genetic ; Male ; Rats ; Rats, Inbred SHR/genetics ; Rats, Inbred Strains/genetics ; Retina/pathology* ; Retinal Degeneration/pathology
Abstract
The pathogenesis of diabetic retinopathy has not been fully explained. The earliest histological lesion is the loss of intramural pericytes and thickening of the basement membrane. Increased activity of the polyol pathway is a probable mechanism for these two abnormalities. Investigations have suffered from the lack of an exact animal model simulating the human condition. Examination of the retina in the spontaneously diabetic SHR/N:Mcc-cp rat demonstrated degeneration and loss of intramural pericytes, a progressive increase in basement membrane thickness, and microinfarctions with an area of non-perfusion. Therefore, this model may be used to clarify the biochemical mechanisms linking the metabolic abnormalities of diabetes and retinopathy.
Files in This Item:
T199803202.pdf Download
DOI
10.3349/ymj.1998.39.5.453
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Woong(권오웅)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177095
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