Cited 9 times in
Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오웅 | - |
dc.date.accessioned | 2020-07-02T17:53:04Z | - |
dc.date.available | 2020-07-02T17:53:04Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177095 | - |
dc.description.abstract | The pathogenesis of diabetic retinopathy has not been fully explained. The earliest histological lesion is the loss of intramural pericytes and thickening of the basement membrane. Increased activity of the polyol pathway is a probable mechanism for these two abnormalities. Investigations have suffered from the lack of an exact animal model simulating the human condition. Examination of the retina in the spontaneously diabetic SHR/N:Mcc-cp rat demonstrated degeneration and loss of intramural pericytes, a progressive increase in basement membrane thickness, and microinfarctions with an area of non-perfusion. Therefore, this model may be used to clarify the biochemical mechanisms linking the metabolic abnormalities of diabetes and retinopathy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Diabetic Retinopathy/pathology* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hybridization, Genetic | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Inbred SHR/genetics | - |
dc.subject.MESH | Rats, Inbred Strains/genetics | - |
dc.subject.MESH | Retina/pathology* | - |
dc.subject.MESH | Retinal Degeneration/pathology | - |
dc.title | Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Soon Hyun Kim | - |
dc.contributor.googleauthor | Young Kwang Chu | - |
dc.contributor.googleauthor | Oh Woong Kwon | - |
dc.contributor.googleauthor | Sylvia A McCune | - |
dc.contributor.googleauthor | Frederick H Davidorf | - |
dc.identifier.doi | 10.3349/ymj.1998.39.5.453 | - |
dc.contributor.localId | A00235 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 821795 | - |
dc.contributor.alternativeName | Kwon, Oh Woong | - |
dc.contributor.affiliatedAuthor | 권오웅 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 453 | - |
dc.citation.endPage | 462 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.39(5) : 453-462, 1998 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.