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Opposite effects of pinealectomy and melatonin administration on brain damage following cerebral focal ischemia in rat

Authors
 Jin-Yang Joo  ;  Tolga Uz  ;  Hari Manev 
Citation
 RESTORATIVE NEUROLOGY AND NEUROSCIENCE, Vol.13(3~4) : 185-191, 1998 
Journal Title
 RESTORATIVE NEUROLOGY AND NEUROSCIENCE 
ISSN
 0922-6028 
Issue Date
1998
Keywords
pineal gland ; pinealectomy ; melatonin ; DNA damage ; stroke ; rat
Abstract
The endocrine system has been recognized as an important factor that may contribute to the outcome of stroke. We tested in rats the hypothesis that the pineal gland and/or its hormone melatonin may affect the outcome of a transient cerebral arteries occlusion (CerAO). Reversible 90 min focal ischemia was produced using a three-vessel occlusion method. Surgically or sham pinealectomized rats were exposed to CerAO 15 days after surgery. Melatonin (4 x 2.5 mg/kg: 30 min prior to onset of CerAO, immediately after recirculation was established, and 1 and 2 hr later) or its vehicle were administered intraperitoneally. The outcome of CerAO was assessed by quantitative assay of DNA damage or by Nissl staining and measurement of the infarct volume. Pinealectomy increased both the extent of DNA damage and the infarct volume; administration of melatonin to pinealectomized rats reduced both these markers of brain injury. We propose that the pineal endocrine system may influence the outcome of stroke. The mechanism of action and the pathophysiological role of this system, e.g., in aging, should be further characterized.
Full Text
https://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn00065
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Joo, Jin Yang(주진양)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177006
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