Cited 0 times in
Opposite effects of pinealectomy and melatonin administration on brain damage following cerebral focal ischemia in rat
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 주진양 | - |
dc.date.accessioned | 2020-07-02T17:43:46Z | - |
dc.date.available | 2020-07-02T17:43:46Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0922-6028 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177006 | - |
dc.description.abstract | The endocrine system has been recognized as an important factor that may contribute to the outcome of stroke. We tested in rats the hypothesis that the pineal gland and/or its hormone melatonin may affect the outcome of a transient cerebral arteries occlusion (CerAO). Reversible 90 min focal ischemia was produced using a three-vessel occlusion method. Surgically or sham pinealectomized rats were exposed to CerAO 15 days after surgery. Melatonin (4 x 2.5 mg/kg: 30 min prior to onset of CerAO, immediately after recirculation was established, and 1 and 2 hr later) or its vehicle were administered intraperitoneally. The outcome of CerAO was assessed by quantitative assay of DNA damage or by Nissl staining and measurement of the infarct volume. Pinealectomy increased both the extent of DNA damage and the infarct volume; administration of melatonin to pinealectomized rats reduced both these markers of brain injury. We propose that the pineal endocrine system may influence the outcome of stroke. The mechanism of action and the pathophysiological role of this system, e.g., in aging, should be further characterized. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOS Press | - |
dc.relation.isPartOf | RESTORATIVE NEUROLOGY AND NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Opposite effects of pinealectomy and melatonin administration on brain damage following cerebral focal ischemia in rat | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Jin-Yang Joo | - |
dc.contributor.googleauthor | Tolga Uz | - |
dc.contributor.googleauthor | Hari Manev | - |
dc.contributor.localId | A03959 | - |
dc.relation.journalcode | J02619 | - |
dc.identifier.eissn | 1878-3627 | - |
dc.identifier.pmid | 12671279 | - |
dc.identifier.url | https://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn00065 | - |
dc.subject.keyword | pineal gland | - |
dc.subject.keyword | pinealectomy | - |
dc.subject.keyword | melatonin | - |
dc.subject.keyword | DNA damage | - |
dc.subject.keyword | stroke | - |
dc.subject.keyword | rat | - |
dc.contributor.alternativeName | Joo, Jin Yang | - |
dc.contributor.affiliatedAuthor | 주진양 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3~4 | - |
dc.citation.startPage | 185 | - |
dc.citation.endPage | 191 | - |
dc.identifier.bibliographicCitation | RESTORATIVE NEUROLOGY AND NEUROSCIENCE, Vol.13(3~4) : 185-191, 1998 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.