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Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis

Authors
 Kwanghyoun Park  ;  Kwan Sik Chun  ;  Jong In Yook  ;  Young Joon Surh 
Citation
 ANTICANCER RESEARCH, Vol.18(6A) : 4201-4205, 1998 
Journal Title
 ANTICANCER RESEARCH 
ISSN
 0250-7005 
Issue Date
1998
MeSH
9,10-Dimethyl-1,2-benzanthracene/toxicity ; Acetone/toxicity ; Animals ; Capsaicin/toxicity* ; Capsicum/toxicity* ; Carcinogens/toxicity* ; Female ; Hyperplasia ; Inflammation ; Mice ; Mice, Inbred ICR ; Papilloma/chemically induced* ; Papilloma/pathology ; Plants, Medicinal* ; Skin/drug effects ; Skin/pathology* ; Skin Neoplasms/chemically induced* ; Skin Neoplasms/pathology ; Tetradecanoylphorbol Acetate/toxicity ; Time Factors
Abstract
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the major pungent principle of hot peppers of the genus Capsicum. There have been numerous investigations to evaluate the effects of capsaicin on experimental carcinogenesis and mutagenesis, but the results are discordant. In the present study, we have assessed the tumor promoting potential of capsaicin using a two stage mouse skin carcinogenesis model. Repeated applications of capsaicin (10 mumol) onto the shaven backs of female ICR mice following a single-initiation dose of 7,12-dimethylbenz[alpha]anthracene did not cause any significant increase in papilloma formation and abnormal hyperplastic or inflammatory skin lesions, compared with the solvent control. Furthermore, the topical application of capsaicin did not induce the epidermal ornithine decarboxylase activity, suggesting that it lacks tumor-promotional activity. On the contrary, the compound ameliorated the mouse skin carcinogenesis when given simultaneously with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176906
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